Reward Circuitry Activation by Noxious Thermal Stimuli

Becerra, Lino; Breiter, Hans C.; Wise, Roy A.; González, Ramón; Borsook, David

doi:10.1016/s0896-6273(01)00533-5

Cited by 450 publications

(412 citation statements)

References 107 publications

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“…Coghill and colleagues demonstrated with PET that pain is a distributed bilateral process, while for non-noxious heat stimulation, only contralateral activation is observed (Coghill et al 1999). In addition, other investigators have found temporal differences for noxious and non-noxious cortical responses (Becerra et al 2001;Chen et al 2006). These studies seem to indicate that the temporal response to noxious stimuli in S1 is distinct from innocuous stimuli; pain seems to produce a prolonged or biphasic response usually extending beyond the duration of the stimulus whereas innocuous stimuli produce a response similar to other evoked hemodynamic responses.…”

Section: Introductionmentioning

confidence: 93%

“…A 3×3 cm 2 thermode (TSA-2001, Medoc Inc., Haifa, Israel) was used to deliver the painful 46 °C thermal stimuli. This equipment has been utilized in other fMRI pain experiments (Becerra et al 2001). The thermal probe was lowered down onto the hand of the subject upon prompting and removed at the end of each stimulus.…”

Section: Paradigmmentioning

confidence: 99%

“…Group statistics were obtained by the following approach: For brush, individual HbO changes to the 26 stimuli were fitted linearly with an explanatory variable (EV) constructed from the temporal profile of the stimuli convoluted with a standard hemodynamic response (gamma function with delay of 6 s and standard deviation of 3s, see Becerra et al, 2001). For heat, following our previous fMRI study, two EV's were used (one delayed 10 seconds from the other, see Becerra et al, 2001).…”

Section: Hemodynamic Model Decomposition and Group Statistical Analysmentioning

confidence: 99%

“…For heat, following our previous fMRI study, two EV's were used (one delayed 10 seconds from the other, see Becerra et al, 2001). …”

Section: Hemodynamic Model Decomposition and Group Statistical Analysmentioning

confidence: 99%

“…We wished to determine whether robust signals could be measured using this approach and whether or not signals in somatosensory regions could be differentiated based on their duration or pattern. For example we have previously reported a biphasic BOLD response to noxious heat with fMRI that is not observed to mechanical or non-noxious thermal stimuli (Becerra et al, 1999(Becerra et al, , 2001). In addition, given the ability of DOT to measure changes in multiple cortical regions, we also wished to determine if we could measure changes in frontal regions that might provide additional information on emotional processing of pain in a similar manner to that reported for fMRI,…”

Section: Introductionmentioning

confidence: 96%

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Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

et al. 2008

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Using Diffuse Optical Tomography (DOT) we detected activation in the somatosensory cortex and frontal brain areas following tactile (brush) and noxious heat stimulation. Healthy volunteers received stimulation to the dorsum of the right hand. In the somatosensory cortex area, tactile stimulation produced a robust, contralateral to the stimulus, hemodynamic response with a weaker activation on the ipsilateral side. For the same region, noxious thermal stimuli produced bilateral activation of similar intensity that had a prolonged activation with a two-peak similar to results have been reported with functional MRI. Bilateral activation was observed in the frontal areas, oxyhemoglobin changes were positive for brush stimulation while they were initially negative (contralateral) for heat stimulation. These results suggest that based on the temporal and spatial characteristics of the response in the sensory cortex, it is possible to discern painful from mechanical stimulation using DOT. Such ability might have potential applications in a clinical setting in which pain needs to be assessed objectively (e.g. analgesic efficacy, pain responses during surgery).

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Section: Introductionmentioning

confidence: 93%

Section: Paradigmmentioning

confidence: 99%

Section: Hemodynamic Model Decomposition and Group Statistical Analysmentioning

confidence: 99%

“…For heat, following our previous fMRI study, two EV's were used (one delayed 10 seconds from the other, see Becerra et al, 2001). …”

Section: Hemodynamic Model Decomposition and Group Statistical Analysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

et al. 2008

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Association of a Polymorphism Near CREB1 With Differential Aversion Processing in the Insula of Healthy Participants

Perlis¹

2008

Arch Gen Psychiatry

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Context Previous functional neuroimaging studies have identified a network of brain regions that process aversive stimuli, including anger. A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment–emergent suicidality in men with major depressive disorder, but its functional effects have not been studied. Objective To determine whether this genetic variant is associated with altered brain processing of and behavioral avoidance responses to angry facial expressions. Design and Participants A total of 28 white participants (mean age, 29.2 years; 13 women) were screened using the Structured Clinical Interview for DSM-IV to exclude any lifetime Axis I psychiatric disorder and were genotyped for rs4675690, a single-nucleotide polymorphism near CREB1. Main Outcome Measures Blood oxygenation level–dependent signal by functional magnetic resonance imaging in the amygdala, insula, anterior cingulate, and orbitofrontal cortex during passive viewing of photographs of faces with emotional expressions. To measure approach and avoidance responses to anger, an off-line key-press task that traded effort for viewing time assessed valuation of angry faces compared with other expressions. Results The CREB1-linked single-nucleotide polymorphism was associated with significant differential activation in an extended neural network responding to angry and other facial expressions. The CREB1-associated insular activation was coincident with activation associated with behavioral avoidance of angry faces. Conclusions A polymorphism near CREB1 is associated with responsiveness to angry faces in a brain network implicated in processing aversion. Coincident activation in the left insula is further associated with behavioral avoidance of these stimuli.

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The Missing P in Psychiatric Training

Elman¹,

Zubieta²,

Borsook³

2011

Arch Gen Psychiatry

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105

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Context Pain problems are exceedingly prevalent among psychiatric patients. Moreover, clinical impressions and neurobiological research suggest that physical and psychological aspects of pain are closely related entities. Nonetheless, remarkably few pain-related themes are presently included in psychiatric residency training. Objective Our objective is twofold: (1) to provide clinical and scientific rationale for psychiatric training enrichment with basic tenets of pain medicine and (2) to raise the awareness and sensitivity of clinicians, scientists and educators alike to the important yet unmet clinical and public health need. Results Three lines of translational research evidence, extracted from the comprehensive literature review, are presented in support of the objective. First, the neuroanatomical and functional overlap between pain and emotion/reward/motivation brain circuits suggests integration and mutual modulation of these systems. Second, psychiatric disorders are commonly associated with alterations in pain processing, whereas chronic pain may impair emotional and neurocognitive functioning. Third, pain may serve as a functional probe for unraveling pathophysiological mechanisms inherent in psychiatric morbidity given its stressful nature for the organism. Conclusions Pain training in psychiatry will not only contribute to deeper and more sophisticated insights into pain syndromes but also into psychiatric morbidity at large regardless of patients’ pain status. Furthermore, it will ease artificial boundaries separating psychiatric and medical formulations of brain disorders, thus fostering cross-fertilizing interactions between specialists in various disciplines entrusted with the care of pain patients.

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Reward Circuitry Activation by Noxious Thermal Stimuli

Cited by 450 publications

References 107 publications

Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems

Association of a Polymorphism Near CREB1 With Differential Aversion Processing in the Insula of Healthy Participants

The Missing P in Psychiatric Training

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