Reward-associated excitation and pain-associated inhibition lasting seconds in rat medial pallidal units

Keene, James J.

doi:10.1016/0014-4886(75)90197-1

Cited by 11 publications

(9 citation statements)

References 21 publications

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“…However, there is no assurance that the cortical populations inhibited by midbrain stimuli and excitatory to nucleus reticularis are identical or overlap. Second, the present findings confirm a previous report of prolonged RET-elicited inhibition of thalamic ventral anterior-ventral lateral units (Keene, 1975). These nuclei might contribute excitatory inputs to nucleus reticularis.…”

Section: Discussionsupporting

confidence: 92%

“…MFB stimuli have elicited prolonged unit responses similar to the RET-elicited effects described above, in nucleus reticularis, cerebral cortex (Keene, 1973b), midbrain reticular formation (Keene, 1973b), and ventral anterior-ventral lateral thalamus (Keene, 1975). These MFB effects, plus the finding of greater MFB-RET convergence than would be expected by chance and the close correlation between the magnitude of MFB and RET effects across cells, suggest that the stimuli might be activating similar or overlapping mechanisms, responsible for the decreased firing observed in nucleus reticularis.…”

Section: Discussionmentioning

confidence: 69%

“…(Olds and Olds, 1963), the similarity of long-lasting unit responses to the two stimuli might partially exclude the interpretation that the responses contain significant information pertaining to the rewarding and aversive features per se of the stimuli. The widespread anatomical distribution of these unit responses (Keene, 1973a, b;1975), along with desynchronization of slow wave recordings, suggests that the communality in the RET and MFB effects might be related to an arousal dimension.…”

Section: Discussionmentioning

confidence: 99%

“…citation, lasting up to 10 or more sec, converged on single neurons localized in intralaminar thalamus (Keene, 1973b). Prolonged opposite unit responses have also been found to be confined to medial pallidurn (n. entopeduncularis) in rat (Keene, 1975). The medial pallidal responses were the inverse of those in intralaminar thalamus: that is, MFB-elicited excitation and RET-elicited inhibition.…”

Section: Introductionmentioning

confidence: 87%

“…The experimental procedures and data analysis were similar to those of previous studies where detailed description may be found (Keene, 197313;1975). In brief, the unanesthetized cerveau isole preparation, with the section posterior to the colliculi and anterior to the fifth nerve, was used because of its simplicity, lack of requirement for anesthetic or artificial respiration, and general stability of slow-wave signs of arousal level.…”

Section: Methodsmentioning

confidence: 99%

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Prolonged unit responses in thalamic reticular, ventral, and posterior nuclei following lateral hypothalamic and midbrain reticular stimulation

Keene

1975

J of Neuroscience Research

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In unanesthetized postcollicular cerveau isole rats, prolonged responses over 10 sec periods following intracranial stimulation (0.2 sec, 100 Hz, 0.5 msec. 600 muA cathodal pulses) were studied with extracellular recordings of 150 nucleus reticularis and 122 ventral and posterior thalamic units. After medial forebrain bundle (MFB) or midbrain reticular (RET) stimulation, most nucleus reticularis units showed significantly decreased firing, and the MFB and RET effects converged on 64%. None was excited. In ventral and posterior thalamus, however, long-lasting unit responses were mixed. MFB and RET stimuli elicited significantly increased firing in 17% and 20% of the units, respectively, and decreased firing in 21% and 16%, respectively. Convergence of MFB- and RET-elicited responses occurred in 25% of the cells, but none showed convergence of opposite responses which might reflect believed motivational differences between the stimuli. Similar stimuli delivered to ventral medial thalamus evoked pronounced excitation of nucleus reticularis discharge, contrasting the MFB and RET effects and confirming previous reports by others. The substantial responses elicited by MFB and RET stimuli in nucleus reticularis fulfill previously proposed criteria for definition of an arousal dimension in terms of single cell activity. The similarity of MFB and RET effects in the posterior nucleus of thalamus raises questions regarding its role in nociception.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 69%