Reward anticipation in individuals with subclinical psychotic experiences: A functional MRI approach

Michielse, Stijn; Lange, Iris; Bakker, Jindra; Goossens, Liesbet; Verhagen, Stijn; Papalini, Silvia; Wichers, Marieke; Lieverse, Ritsaert; Schruers, Koen; Amelsvoort, Thérèse van; Os, Jim van; Murray, Graham K.

doi:10.1016/j.euroneuro.2019.10.002

Cited by 2 publications

(11 citation statements)

References 77 publications

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“…High interpersonal schizotypy scorers displayed less activation in the right postcentral gyrus, left para-hippocampal gyrus, and left putamen (Yan et al, 2016). During a high gain reward condition, high cognitive-perceptual schizotypy scorers showed lower activation in the right supramarginal gyrus, right insula, and right putamen, compared with low scorers (Michielse et al, 2019). Finally, during high gain anticipation, low cognitive-perceptual schizotypy scorers displayed higher brain activation in the ventral striatum compared with high cognitive-perceptual schizotypy scorers and schizophrenia patients (Simon et al, 2015).…”

Section: Resultsmentioning

confidence: 90%

“…Of the 17 studies investigating functional brain activation during nonsocial cognitive tasks, total schizotypy scores were assessed in five studies using the SPQ (Fink et al, 2014; Kirschner et al, 2018), the O-LIFE (Meyhöfer et al, 2015; Park & Waldie, 2017), and the SIS (Thermenos et al, 2013). Cognitive-perceptual schizotypy was assessed in 11 studies using the RISC (Aichert et al, 2012; Landin-Romero et al, 2015), the CAPE (Michielse et al, 2019; Papanastasiou et al, 2018; Simon et al, 2015), the SPQ (Lavigne et al, 2020; Yan et al, 2016), the O-LIFE (Park et al, 2015), the STA (Ettinger et al, 2013), a combination of the PAS and the MIS (Karcher, Hua, et al, 2019), or psychoticism subscale of the EPQ-R (Kumari et al, 2008). Interpersonal schizotypy was measured in three studies, using the O-LIFE (Park et al, 2015), the SPQ (Yan et al, 2016), and the extraversion subscale of the EPQ-R (Kumari et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

“…In one study, the 22 highest and 22 lowest scorers on the SPQ among the original sample were chosen to form high and low schizotypy groups (Fink et al, 2014). Scores above 10 on the CAPE (frequency scale) were considered high in one study (Michielse et al, 2019). One study formed three groups reflecting high (scores more than 1 SD s above sample mean), intermediate (scores less than 1 SD or below sample mean), and low schizotypy (scores more than 1 SD below sample mean; Simon et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…It has also been recommended that the WB and ROI methods should be used in tandem (Kubicki et al, 2002). One fMRI study reviewed here did use both approaches (Michielse et al, 2019), reporting significant differences in brain activation between schizotypy groups when using the whole-brain approach but not when focusing on hypothesized brain regions-of-interest.…”

Section: Discussionmentioning

confidence: 99%

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Structural and functional neural correlates of schizotypy: A systematic review.

Tonini¹,

Quidé²,

Kaur³

et al. 2021

Psychological Bulletin

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Schizotypy refers to a multidimensional construct that spans a range of cognitive, behavioral, and personality features, representing liability to psychosis on a continuum between health and illness. Schizotypy has been associated with functional and structural brain alterations as potential intermediate phenotypes on the developmental path to psychosis. We scanned the literature between February 2019 and August 1, 2020 using PubMed, Medline, APA PsycINFO, and ProQuest. We identified eligible articles conducted on participants assessed with psychometric schizotypy across the health-illness spectrum and reporting a direct statistic between schizotypy and a structural, task-related, or functional magnetic resonance imaging brain measure. Articles not peer-reviewed and not written in English were excluded. We systematically reviewed 84 studies that determined the changes in gray matter, brain activation, and connectivity associated with schizotypy in both healthy and clinical cohorts. Morphological and functional changes in the default and the frontoparietal networks, specifically frontal and temporal cortices, were most frequently associated with schizotypy. Yet, we were unable to identify consistent patterns of morphological or functional brain aberration associated with schizotypy, due to methodological differences between studies in the conceptualization and measurement of schizotypy. Efforts toward greater methodological concordance in future neuroimaging research of schizotypy are needed to improve the identification of brain-based endophenotypes for schizophrenia. Public Significance StatementThis systematic review indicates that schizotypy is associated with structural and functional changes in frontal and temporal brain regions, extending to several additional regions.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Structural and functional neural correlates of schizotypy: A systematic review.

Tonini¹,

Quidé²,

Kaur³

et al. 2021

Psychological Bulletin

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“…Although previous studies have identified several likely neural substrates for monetary anticipation in CHR individuals to date, the results are inconclusive. Several fMRI experiments have demonstrated abnormal brain activity in mesocorticolimbic circuitry during anticipation of reward-capturing “motivational salience” in the CHR population ( Smieskova et al, 2015 ; Michielse et al, 2019 ). Alterations in motivational salience processing in the VS and cortical regions (such as the prefrontal cortex and cingulate cortex) have been described in prepsychotic individuals ( Bourque et al, 2017 ; Schmidt et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia

Zeng

Yan

You

et al. 2023

International Journal of Neuropsychopharmacology

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Background Aberrant striatal responses to reward anticipation have been observed in schizophrenia. However, it is unclear whether these dysfunctions predate the onset of psychosis, and whether reward anticipation is impaired in individuals at clinical high risk for schizophrenia (CHR). Methods To examine the neural correlates of monetary anticipation in the prodromal phase of schizophrenia, we performed a whole-brain meta-analysis of thirteen functional neuroimaging studies that compared reward anticipation signals between CHR individuals and healthy controls (HC). Three databases (PubMed, Web of Science, and ScienceDirect) were systematically searched from 1 January 2000 to 1 May 2022. Results Thirteen whole-brain functional magnetic resonance imaging (fMRI) studies including 318 CHR subjects and 426 HC were identified through comprehensive literature searches. Relative to HC, CHR subjects showed increased brain responses in the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC), and decreased activation in the mesolimbic circuit, including the putamen, parahippocampal gyrus, insula, cerebellum, and supramarginal gyrus, during reward anticipation. Conclusions Our findings in the CHR group confirmed the existence of abnormal motivational-related activation during reward anticipation, thus demonstrating the pathophysiological characteristics of the risk populations. These results have the potential to lead to the early identification and more accurate prediction of subsequent psychosis, as well as a deeper understanding of the neurobiology of high-risk state of psychotic disorder.

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Reward anticipation in individuals with subclinical psychotic experiences: A functional MRI approach

Cited by 2 publications

References 77 publications

Structural and functional neural correlates of schizotypy: A systematic review.

Structural and functional neural correlates of schizotypy: A systematic review.

A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia

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