Abstract:Many families of lipid isomers remain unresolved by contemporary liquid chromatography-mass spectrometry ap-proaches, leading to a significant underestimation of structural diversity within the lipidome. While ion-mobility coupled to mass spectrometry has provided an additional dimension of lipid isomer resolution, some isomers require resolving power beyond the capabilities of conventional platforms. Here we present the application of high-resolution travelling-wave ion mobility for the separation of lipid is… Show more
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