Revolutionizing orofacial pain management: the promising potential of stem cell therapy

Ren, Ke; Vickers, Russel; Murillo, Josue; Ruparel, Nikita B.

doi:10.3389/fpain.2023.1239633

Cited by 2 publications

(2 citation statements)

References 161 publications

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“…Secondly, it opens avenues for research into the integration of psychological and social factors in pain management, which is relatively unexplored in COFP. This could lead to new treatment modalities that address the patient's overall well-being [133][134][135].…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

Canfora,

Ottaviani,

Calabria

et al. 2023

Biomedicines

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In exploring chronic orofacial pain (COFP), this review highlights its global impact on life quality and critiques current diagnostic systems, including the ICD-11, ICOP, and ICHD-3, for their limitations in addressing COFP’s complexity. Firstly, this study outlines the global burden of chronic pain and the importance of distinguishing between different pain types for effective treatment. It then delves into the specific challenges of diagnosing COFP, emphasizing the need for a more nuanced approach that incorporates the biopsychosocial model. This review critically examines existing classification systems, highlighting their limitations in fully capturing COFP’s multifaceted nature. It advocates for the integration of these systems with the DSM-5’s Somatic Symptom Disorder code, proposing a unified, multidisciplinary diagnostic approach. This recommendation aims to improve chronic pain coding standardization and acknowledge the complex interplay of biological, psychological, and social factors in COFP. In conclusion, here, we highlight the need for a comprehensive, universally applicable classification system for COFP. Such a system would enable accurate diagnosis, streamline treatment strategies, and enhance communication among healthcare professionals. This advancement holds potential for significant contributions to research and patient care in this challenging field, offering a broader perspective for scientists across disciplines.

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Section: Discussion and Future Directionsmentioning

confidence: 99%

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

Canfora,

Ottaviani,

Calabria

et al. 2023

Biomedicines

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“…The combination of SCT and non-opioid anesthesia for chronic pain management has not been extensively studied. However, research suggests that combining non-opioid analgesics with SCT could provide an effective treatment option for patients with chronic pain by reducing the need for opioids [41][42][43].…”

Section: Combined Use For Pain Managementmentioning

confidence: 99%

Exploring the Potential of Stem Cell Therapy and Non-Opioid Anesthesia and Pain Reduction: Reducing the Negative Impact on the Individual and Society

Kerna,

Flores,

Azi

et al. 2024

ejmhr

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The opioid epidemic poses a significant public health challenge, stemming from the widespread misuse and abuse of opioids for pain management. Stem cell therapy (SCT) and non-opioid anesthesia emerge as promising alternatives to traditional opioid-based treatments, offering effective pain relief while mitigating the risks of addiction and overdose. SCT involves undifferentiated cells, which can differentiate into various cell types to promote tissue repair and alleviate pain. Non-opioid anesthesia employs techniques such as regional anesthesia and multimodal analgesia to manage pain during surgeries without relying on opioids.Both SCT and non-opioid anesthesia demonstrate advantages in reducing opioid dependence and improving patient outcomes. SCT releases neurotrophic factors for neuropathic pain relief and can prevent opioid tolerance, while non-opioid anesthesia provides robust pain control with fewer side effects.Although further research is needed to optimize their use, the integration of SCT and non-opioid anesthesia affords a comprehensive approach to addressing the opioid crisis. By reducing opioid prescriptions and promoting safer pain management practices, these interventions not only benefit individual patients but also alleviate the socioeconomic burden of opioid-related complications. Ethical considerations, such as informed consent and patient autonomy, are essential in ensuring these alternative treatments’ responsible and equitable implementation. SCT and non-opioid anesthesia represent significant advancements in combating the opioid epidemic and improving public health outcomes.Abbreviations: CPSP: Chronic Post-Surgical Pain; ESCs: Embryonic Stem Cells; HSCs: Hematopoietic Stem Cells; MSCs: Mesenchymal Stem Cells; NSAIDs: Nonsteroidal Anti-Inflammatory Drugs; OFA: Opioid-Free Anesthesia; PONV: Postoperative Nausea and Vomiting; QoL: Quality of Life; SCT: Stem Cell Therapy; TKA: Total Knee Arthroplasty

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Revolutionizing orofacial pain management: the promising potential of stem cell therapy

Cited by 2 publications

References 161 publications

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

Exploring the Potential of Stem Cell Therapy and Non-Opioid Anesthesia and Pain Reduction: Reducing the Negative Impact on the Individual and Society

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