Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

Alshangiti, Dalal Mohamed; El-damhougy, Tasneam K.; Zaher, Ahmed; Madani, Mohamed; Mohamady ghobashy, Mohamed

doi:10.1039/d3ra07391b

Cited by 30 publications

(8 citation statements)

References 111 publications

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“…In that context, a hyaluronic emulgel could be the ideal vehicle, as an emulsion allows for the incorporation of hydrophilic/lipophilic substances due to its biphasic nature, and hyaluronic acid permits the retention of active substances longer on the skin, prolonging their action [32]. Additionally, semi-solid formulations prepared using this polymer are characterized by excellent sensory and rheological properties and have shown excellent qualities as wound-healing formulations [33,34].…”

Section: Resultsmentioning

confidence: 99%

“…The pH values were observed to be 5.2-6.3. Moreover, all pH values were around that of the skin pH (4.5-6), suggesting an acceptable and non-irritating value [34]. Moreover, the creamy formulations that did not show phase separation were those with a higher hyaluronic acid concentration (1.5% w/v) with a viscosity of around 3020 ± 7.4 mPa•s (Figure 2).…”

Section: Physical Evaluationmentioning

confidence: 91%

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A New Hyaluronic Emulgel of Hesperetin for Topical Application—An In Vitro Evaluation

Taléns-Visconti,

Belarbi,

Díez-Sales

et al. 2024

JFB

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The present study aimed to formulate and characterize a hesperetin formulation to achieve adequate deposition and retention of hesperetin in the epidermis as a target for some cosmetic/dermatological actions. To derive the final emulgel, various formulations incorporating different proportions of Polysorbate 80 and hyaluronic acid underwent testing through a Box–Behnken experimental design. Nine formulations were created until the targeted emulgel properties were achieved. This systematic approach, following the principles of a design of experiment (DoE) methodology, adheres to a quality-by-design (QbD) paradigm, ensuring a robust and purposeful formulation and highlighting the commitment to a quality-driven design approach. The emulsions were developed using the phase inversion method, optimizing the emulgel with the incorporation of hyaluronic acid. Physically stable optimized emulgels were evaluated for their globule size, surface charge, viscosity, pH, electrical conductivity, and hesperetin content. These assays, along with the temperature swing test, were used to select the optimal formulation. It was characterized by a droplet size, d[4,3], of 4.02 μm, a Z-potential of −27.8 mV, an O/W sign, a pH of 5.2, and a creamy texture and proved to be stable for at least 2 months at room temperature. Additionally, in vitro release kinetics from the selected emulgel exhibited a sustained release profile of hesperetin. Skin assays revealed adequate retention of hesperetin in the human epidermis with minimum permeation. Altogether, these results corroborate the promising future of the proposed emulgel in cosmetic or dermatological use on healthy or diseased skin.

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Section: Resultsmentioning

confidence: 99%

Section: Physical Evaluationmentioning

confidence: 91%

A New Hyaluronic Emulgel of Hesperetin for Topical Application—An In Vitro Evaluation

Taléns-Visconti,

Belarbi,

Díez-Sales

et al. 2024

JFB

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“…The constituents and arrangement of self-healing hydrogels demonstrate variability contingent upon the targeted application and desired functionalities. The essential elements and methodologies consistently employed in their formulation encompass distinct components [360,361]:…”

Section: Clinical Applications Of Regenerative Hydrogelsmentioning

confidence: 99%

“…Self-healing hydrogels have demonstrated various applications in therapeutic domains [360,[362][363][364][365]:…”

Section: Clinical Applications Of Regenerative Hydrogelsmentioning

confidence: 99%

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Olteanu,

Neacșu,

Joița

et al. 2024

IJMS

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This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on the treatment of skin wounds. Regenerative hydrogels, composed mainly of water-absorbing polymers, have garnered attention in wound healing, particularly for skin wounds. Their unique properties make them well suited for tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist wound environment for optimal healing, and facilitating cell migration, and proliferation. Biocompatibility is a key feature, minimizing adverse reactions and promoting the natural healing process. Acting as a supportive scaffold for cell growth, hydrogels mimic the extracellular matrix, aiding the attachment and proliferation of cells like fibroblasts and keratinocytes. Engineered for controlled drug release, hydrogels enhance wound healing by promoting angiogenesis, reducing inflammation, and preventing infection. The demonstrated acceleration of the wound healing process, particularly beneficial for chronic or impaired healing wounds, adds to their appeal. Easy application and conformity to various wound shapes make hydrogels practical, including in irregular or challenging areas. Scar minimization through tissue regeneration is crucial, especially in cosmetic and functional regions. Hydrogels contribute to pain management by creating a protective barrier, reducing friction, and fostering a soothing environment. Some hydrogels, with inherent antimicrobial properties, aid in infection prevention, which is a crucial aspect of successful wound healing. Their flexibility and ability to conform to wound contours ensure optimal tissue contact, enhancing overall treatment effectiveness. In summary, regenerative hydrogels present a promising approach for improving skin wound healing outcomes across diverse clinical scenarios. This review provides a comprehensive analysis of the benefits, mechanisms, and challenges associated with the use of regenerative hydrogels in the treatment of skin wounds. In this review, the authors likely delve into the application of rational design principles to enhance the efficacy and performance of hydrogels in promoting wound healing. Through an exploration of various methodologies and approaches, this paper is poised to highlight how these principles have been instrumental in refining the design of hydrogels, potentially revolutionizing their therapeutic potential in addressing skin wounds. By synthesizing current knowledge and highlighting potential avenues for future research, this review aims to contribute to the advancement of regenerative medicine and ultimately improve clinical outcomes for patients with skin wounds.

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“…Tremendous progress was made regarding novel and unique strategies, such as advanced materials that are devised, tested, and thoroughly examined to improve safety and effectiveness in various biomedical applications. These materials are carefully engineered with specific physical, chemical, or biological properties to prevent and treat various diseases [1,2]. Hydrogels represent a cutting-edge and highly promising subset of advanced materials that is worthy of in-depth exploration [3].…”

Section: Introductionmentioning

confidence: 99%

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Kruczkowska,

Gałęziewska,

Grabowska

et al. 2024

Gels

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Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative and distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization in drug encapsulation, transport, and controlled release, which is complemented by their biocompatibility, biodegradability, and non-immunogenic nature. Stimuli-responsive hydrogels, also known as smart hydrogels, have strictly regulated release patterns since they respond and adapt based on various external stimuli. Moreover, they can imitate the intrinsic tissues’ mechanical, biological, and physicochemical properties. These characteristics allow stimuli-responsive hydrogels to provide cutting-edge, effective, and safe treatment. Constant progress in the field necessitates an up-to-date summary of current trends and breakthroughs in the biomedical application of stimuli-responsive chitosan-based hydrogels, which was the aim of this review. General data about hydrogels sensitive to ions, pH, redox potential, light, electric field, temperature, and magnetic field are recapitulated. Additionally, formulations responsive to multiple stimuli are mentioned. Focusing on chitosan-based smart hydrogels, their multifaceted utilization was thoroughly described. The vast application spectrum encompasses neurological disorders, tumors, wound healing, and dermal infections. Available data on smart chitosan hydrogels strongly support the idea that current approaches and developing novel solutions are worth improving. The present paper constitutes a valuable resource for researchers and practitioners in the currently evolving field.

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Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

Abstract: Nanocomposite hydrogel biomaterials represent an exciting frontier in biomedicine, offering solutions to longstanding challenges.

Cited by 30 publications

References 111 publications

A New Hyaluronic Emulgel of Hesperetin for Topical Application—An In Vitro Evaluation

A New Hyaluronic Emulgel of Hesperetin for Topical Application—An In Vitro Evaluation

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

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