Revisiting the tuberculosis and leprosy cross-immunity hypothesis: Expanding the dialogue between immunology and paleopathology

Crespo, Fabián; White, Jacob C; Roberts, Charlotte A.

doi:10.1016/j.ijpp.2019.05.005

Cited by 8 publications

(4 citation statements)

References 139 publications

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“…No se observan macroporos o aumento del diámetro de los forámenes nutricios, por lo que se descarta una lesión de origen vascular. Tampoco se evidencia presencia de cloaca ni de invasión en la cavidad de la médula por la reacción del hueso, lo que permite descartar un origen infeccioso de tipo bacteriano como la osteomielitis o de otras enfermedades que dejan marcas (Crespo et al 2019;Ortner, 2003). Se descarta una lesión de tipo neoplásica osteoblástica u osteoclástica, ya que no se observan formaciones de hueso delimitadas o desorganizadas (Ortner, 2003).…”

Section: Análisis Paleopatológicounclassified

Bioarqueologia y paleopatologia de los cazadores-recolectores del sitio Cueva de Plaza: revisión y nuevos aportes

Evans¹,

Zela²,

Scheinsohn³

2023

Rev. Mus. Antrop.

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La Cueva de Plaza es el primer sitio con inhumaciones múltiples datado en momentos históricos para el valle del Genoa (Chubut, Argentina). En este trabajo se da a conocer el análisis bioarqueológico final de los restos óseos humanos y el análisis paleopatológico detallado de esas muestras. La estructura del registro bioarqueológico permite plantear la posibilidad de que los individuos representados hayan fallecido de manera penecontemporánea o en un rango de tiempo acotado, mientras que el análisis paleopatológico permitió detectar dos lesiones traumáticas, líneas de hipoplasia del esmalte dental y una alteración congénita. Las características de este contexto se discuten en el marco general del modelo de redes de transmisión cultural postuladas a partir del arte rupestre del Noroeste Patagónico para el Holoceno tardío y su correspondencia con el registro bioarqueológico de sitios vecinos.

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Section: Análisis Paleopatológicounclassified

Bioarqueologia y paleopatologia de los cazadores-recolectores del sitio Cueva de Plaza: revisión y nuevos aportes

Evans¹,

Zela²,

Scheinsohn³

2023

Rev. Mus. Antrop.

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“…97 Alternatively, there may have been a deleterious effect, such that individuals infected with M. leprae were more likely to suffer an activation of latent M.tb infection and be at risk for a strong selective effect against dual sufferers due to a cell-mediated immune response. 120 Crespo and colleagues 128 discuss moving towards a multifactorial model of explaining the TB-leprosy crossimmunity hypothesis, arguing that cultural and social landscapes in the past were not homogenous, therefore immunological landscapes were not homogeneous either. Thus, the cross-immunity hypothesis does not fully explain leprosy declines in all localities.…”

Section: Selective Mortality and Leprosymentioning

confidence: 99%

Biocultural perspectives of infectious diseases and demographic evolution: Tuberculosis and its comorbidities through history

Doren

2022

Evolutionary Anthropology

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Anthropologists recognize the importance of conceptualizing health in the context of the mutually evolving nature of biology and culture through the biocultural approach, but biocultural anthropological perspectives of infectious diseases and their impacts on humans (and vice versa) through time are relatively underrepresented. Tuberculosis (TB) has been a constant companion of humans for thousands of years and has heavily influenced population health in almost every phase of cultural and demographic evolution. TB in human populations has been dramatically influenced by behavior, demographic and epidemiological shifts, and other comorbidities through history. This paper critically discusses TB and some of its major comorbidities through history within a biocultural framework to show how transitions in human demography and culture affected the disease‐scape of TB. In doing so, I address the potential synthesis of biocultural and epidemiological transition theory to better comprehend the mutual evolution of infectious diseases and humans.

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“…It may also be a general reflection of a decline in the prevalence of leprosy in the Later Medieval Period (14th century onwards), possibly due to the rise of other infectious diseases, such as the Black Death and tuberculosis (Crespo et al, 2019 ; Manchester, 1984 ; Manchester & Roberts, 1989 ; Roberts, 2020 , pp. 291–301; Roffey & Tucker, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Creating communities of care: Sex estimation and mobility histories of adolescents buried in the cemetery of St. Mary Magdalen leprosarium (Winchester, England)

Filipek

Roberts

Montgomery

et al. 2022

American Journal of Biological Anthropology

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Objectives: This study examines the biological sex and geographical origins of adolescents buried at the St Mary Magdalen leprosarium (Winchester, UK). The data are combined with archaeological and palaeopathological evidence to broaden the understanding of mobility and its relationship to leprosy and leprosaria in Medieval England.Materials and Methods: Nineteen individuals ($10-25 at death) with skeletal lesions diagnostic of leprosy were analyzed using standard osteological methods. Amelogenin peptides were extracted from five individuals whose biological sex could not be assessed from macroscopic methods. Enamel samples were analyzed to produce 87 Sr/ 86 Sr and δ 18 O values to explore mobility histories.Results: Amelogenin peptides revealed three males and two females. Tooth enamel samples provided an 87 Sr/ 86 Sr ratio range from 0.7084 to 0.7103 (mean 0.7090, ±0.0012, 2σ). δ 18 O P values show a wide range of 15.6‰-19.3‰ (mean 17.8 ± 1.6‰ 2σ), with corresponding δ 18 O DW values ranging from À9.7‰ to À4.1‰ (mean À6.3 ± 2.4‰ 2σ).Discussion: Amelogenin peptide data reveal the presence of adolescent females with bone changes of leprosy, making them the youngest confirmed females with leprosy in the archaeological record. Results also show at least 12 adolescents were local, and seven were from further afield, including outside Britain. Since St. Mary Magdalen was a leprosarium, it is possible that these people traveled there specifically for care. Archaeological and palaeopathological data support the notion that care was provided at this facility and that leprosy stigma, as we understand it today, may not have existed in this time and place.

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Revisiting the tuberculosis and leprosy cross-immunity hypothesis: Expanding the dialogue between immunology and paleopathology

Cited by 8 publications

References 139 publications

Bioarqueologia y paleopatologia de los cazadores-recolectores del sitio Cueva de Plaza: revisión y nuevos aportes

Bioarqueologia y paleopatologia de los cazadores-recolectores del sitio Cueva de Plaza: revisión y nuevos aportes

Biocultural perspectives of infectious diseases and demographic evolution: Tuberculosis and its comorbidities through history

Creating communities of care: Sex estimation and mobility histories of adolescents buried in the cemetery of St. Mary Magdalen leprosarium (Winchester, England)

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