Revisiting the trafficking of insulin and its receptor in rat liver:in vivoand cell-free studies
Khadija Tahiri,
Françoise Fouque,
Marie-Catherine Postel-Vinay
et al.
Abstract:Endosomes are the main locus where, upon endocytosis in liver cells, insulin and the activated insulin receptor accumulate and insulin is degraded. In this study, ligand and receptor pathways in rat liver have been revisited using analytical subcellular fractionation. Density gradient analysis of microsomal and light mitochondrial fractions confirmed that, upon in vivo uptake into liver, radiolabeled insulin was rapidly translocated from plasma membranes to endosomes. Internalized radiolabeled proinsulin and b… Show more
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