Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression
Yanyan Zhang,
Charles Wang,
Jian Jian Li
Abstract:Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME). Mesenchymal stromal cells (MSCs) play a pivotal role in cancer generation, progression, and immunosuppressive tumor microenvironment. Within the TME, MSCs encompass both resident and circulating counterparts that dynamically communicate and actively participate in TME immunosurveillance and response to ICB. This review aims to reevaluate various facets of MSCs, incl… Show more
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