Revisiting the relationship between complement and ulcerative colitis
Yujie Ma,
Kaicheng Zhang,
Yuanyuan Wu
et al.
Abstract:Ulcerative colitis (UC) is an inflammatory bowel disorder (IBD) characterized by relapsing chronic inflammation of the colon that causes continuous mucosal inflammation. The global incidence of UC is steadily increasing. Immune mechanisms are involved in the pathogenesis of UC, of which complement is shown to play a critical role by inducing local chronic inflammatory responses that promote tissue damage. However, the function of various complement components in the development of UC is complex and even parado… Show more
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