Revisiting the Interaction of γδ T-Cells and B-Cells

Abstract

Right after the discovery of γδ T-cells in 1984, people started asking how γδ T-cells interact with other immune cells such as B-cells. Early reports showed that γδ T-cells are able to help B-cells to produce antibodies and to sustain the production of germinal centers. Interestingly, the presence of γδ T-cells seems to promote the generation of antibodies against "self" and less against challenging pathogens. More recently, these hypotheses were supported using γδ T-cell-deficient mouse strains, in different mouse models of systemic lupus erythematous, and after induction of epithelial cell damage. Together, these studies suggest that the link between γδ T-cells and the production of autoantibodies may be more relevant for the development of autoimmune diseases than generally acknowledged and thus targeting γδ T-cells could represent a new therapeutic strategy. In this review, we focus on what is known about the communication between γδ T-cells and B-cells, and we discuss the importance of this interaction in the context of autoimmunity.

The Neuroimmunology of Guillain-Barré Syndrome and the Potential Role of an Aging Immune System

“…Given that GBS affects more males than females, this could imply that the immune changes seen with aging in males may be a contributing factor to the pathogenesis of GBS via alterations in B cells. In addition, there have been some studies suggesting that γδ T cells and B cells interact (Häcker et al, 1995 ; Rampoldi et al, 2020 ). More specifically, Häcker et al have found that when autologous B cells were used to stimulate γδ T cells in culture, it led to an increase in the percentage of Vδ1 + cells (Häcker et al, 1995 ).…”

Значение Т-Клеток Врожденной Иммунной Системы В Развитии Метавоспаления Жировой Ткани При Ожирении

“…MAIT-клітини становлять практично 10 % пулу Т-клітин периферичної крові людини. Пул MAITклітин у жировій тканині людини значно більший, ніж у периферичній крові [31,55].…”

“…γδTклітини індукують експресію необхідних костимуляторних молекул B-клітин, включаючи CD40L, CD86, CD70, Рисунок 5. Регуляторна роль γδТ-клітин у жировій тканині OX40 та ICOS, а також підвищують активність синтезу IgM В-клітинами [55]. IFN-γ, TNF-α, GM-CSF, IL-4, які продукуються γδТ-клітинами, сприяють диференціюванню моноцитів в антигенпрезентуючі клітини [70].…”

Genetic Influence on the Peripheral Differentiation Signature of Vδ2+ γδ and CD4+ αβ T Cells in Adults

“…Different γδ subsets play multiple roles in immune defense and are involved in tissue surveillance, tumor immunity, anti-microbial responses and autoimmunity [ 11 , 12 ]. In addition to cytokine secretion and cytotoxic activity, γδ T cells can interact with B cells, e.g., to promote immunoglobulin class switching [ 13 , 14 ], and are able to present antigens in an MHC-restricted fashion to αβ T cells [ 15 ]. Furthermore, CD16-expressing γδ T cells mediate antibody-dependent cellular cytotoxicity (ADCC) [ 16 ].…”