Revisiting the interaction of heme with hemopexin: Recommendations for the responsible use of an emerging drug

Detzel, Milena S.; Syllwasschy, Benjamin Franz; Steinbock, Francèl; Ramoji, Anuradha; Hopp, Marie-Thérèse; George, Ajay Abisheck Paul; Neugebauer, Ute; Imhof, Diana

doi:10.1101/2020.04.16.044321

Cited by 2 publications

(2 citation statements)

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“…HeMoQuest (http://bit.ly/hemoquest) (Paul George et al, 2020) was used to identify potential HBMs in the following proteins of SARS-Cov-2: S protein, M protein, E protein, and protein 7a, and human: ACE2 and TMPRSS2. For the selection, the procedure described earlier was applied (Wißbrock et al, 2019;Detzel et al, 2020).…”

Section: Screening For Potential Heme-binding Motifs In Covid-19 Relamentioning

confidence: 99%

“…Under hemolytic conditions such as malaria, sickle cell anemia (SCD), β-thalassemia, and hemorrhage, or in case of severe cellular damage, heme is released in enormous amounts as a result of hemoglobin degradation, leading to a pool of labile heme (Ascenzi et al, 2005;Roumenina et al, 2016). In this case, the heme-detoxifying scavenger proteins, in particular hemopexin, become saturated, which allows heme to execute its wide-ranging effects (Chiabrando et al, 2014;Roumenina et al, 2016;Detzel et al, 2020). The response to heme in this context leads to cytotoxic, procoagulant, vasculotoxic, and proinflammatory effects, as well as an activation of the complement system (Dutra and Bozza, 2014;Roumenina et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Unravelling the debate on heme effects in COVID-19 infections

Hopp

Domingo‐Fernándéz

Gadiya

et al. 2020

Preprint

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The SARS-CoV-2 outbreak was recently declared a worldwide pandemic. Infection triggers the respiratory tract disease COVID-19, which is accompanied by serious changes of clinical biomarkers such as hemoglobin and interleukins. The same parameters are altered during hemolysis, which is characterized by an increase in labile heme. We present two approaches that aim at analyzing a potential link between available heme and COVID-19 pathogenesis. Four COVID-19 related proteins, i.e. the host cell proteins ACE2 and TMPRSS2 as well as the viral protein 7a and S protein, were identified as potential heme binders. We also performed a detailed analysis of the common pathways induced by heme and SARS-CoV-2 by superimposition of knowledge graphs covering heme biology and COVID-19 pathophysiology. Herein, focus was laid on inflammatory pathways, and distinct biomarkers as the linking elements. Finally, the results substantially improve our understanding of COVID-19 infections and disease progression of patients with different clinical backgrounds and expand the diagnostic and treatment options.

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Section: Screening For Potential Heme-binding Motifs In Covid-19 Relamentioning

confidence: 99%