Revisiting the Classic Open Fracture Studies to Correct Misperceptions and Errors

Lundy, Douglas W.

doi:10.5435/jaaos-d-21-00958

Cited by 1 publication

(2 citation statements)

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“…Open fractures, often caused by violent trauma, are accompanied by soft tissue and skin defects. Compared with closed fractures, they carry a higher risk of infection and disability 33,34 . The treatment of open fracture patients must ensure bone healing and functional recovery of limbs while also preventing wound infection 35 .…”

Section: Discussionmentioning

confidence: 99%

“…Compared with closed fractures, they carry a higher risk of infection and disability. 33 , 34 The treatment of open fracture patients must ensure bone healing and functional recovery of limbs while also preventing wound infection. 35 Slow wound healing and various complications in open fracture patients are significant challenges for both victims and medical professionals.…”

Section: Discussionmentioning

confidence: 99%

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Effects of negative pressure wound therapy on wound infection and healing in patients with open fracture wounds: A meta‐analysis

Xu,

2024

International Wound Journal

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A meta‐analysis was conducted to comprehensively evaluate the impact of negative pressure wound therapy (NPWT) on wound infection and healing in patients with open fracture wounds. Computer searches were performed in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the application of NPWT in open fracture wounds, with the search period covering the databases inception to September 2023. Two researchers independently screened the literature, extracted data and conducted quality assessments. Stata 17.0 software was employed for data analysis. Overall, 17 RCTs involving 1814 patients with open fracture wounds were included. The analysis revealed that compared with other treatment methods, NPWT significantly shortened the wound healing time (standardized mean difference [SMD] = −2.86, 95% confidence intervals [CI]: −3.51 to −2.20, p < 0.001) and fracture healing time (SMD = −3.14, 95% CI: −4.49 to −1.79, p < 0.001) in patients with open fracture wounds. It also significantly reduced the incidence of wound infection (odds ratio [OR] = 0.36, 95% CI: 0.23–0.56, p < 0.001) and complications (OR = 0.29, 95% CI: 0.20–0.40, p < 0.001). This study indicates that in the treatment of open fracture wounds, NPWT, compared with conventional treatment methods, can accelerate the healing of wounds and fractures, effectively control infections and reduce the occurrence of complications, demonstrating high safety.

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Section: Discussionmentioning

confidence: 99%