Revisiting roles of mast cells and neural cells in keloid: exploring their connection to disease activity
Eunhye Yeo,
Joonho Shim,
Se Jin Oh
et al.
Abstract:BackgroundMast cells (MCs) and neural cells (NCs) are important in a keloid microenvironment. They might contribute to fibrosis and pain sensation within the keloid. However, their involvement in pathological excessive scarring has not been adequately explored.ObjectivesTo elucidate roles of MCs and NCs in keloid pathogenesis and their correlation with disease activity.MethodsKeloid samples from chest and back regions were analyzed. Single-cell RNA sequencing (scRNA-seq) was conducted for six active keloids (A… Show more
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