Revisiting intracellular calcium signaling semantics

Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity

“…EF-hand proteins help perform cellular functions by maintaining the structural integrity of multimeric protein complexes, altering protein interactions like switches, or simply buffering Ca 2ϩ (5,6). Ultimately, these Ca 2ϩ -dependent processes are controlled by the Ca 2ϩ signal and the Ca 2ϩ binding properties of the protein (7,8). A prime example of such behavior is the increased amplitude and decreased duration of cardiac muscle contraction after a surge of adrenaline.…”

Glioblastoma and calcium signaling - analysis of calcium toolbox expression

“…These included 75 calcium channels, 25 calcium pumps or calcium exchangers, 160 calcium binding proteins belonging to the EF-hand domain family (Haiech et al, 2011). Such a toolbox is by far probably not exhaustive but it facilitates biological interpretation.…”

“…Previous and recent papers have established a generally accepted vocabulary to describe the different elements involved in setting up a specific calcium signal in a given cell and in a given physiological state (for review see (Haiech et al, 2011)). The human genome contains more than 250 genes coding for such elements.…”

“…Given signalosome proteins assemble to form macromolecular complexes, called calcisomes. Such calcisomes are going to be key elements to encode external information into a calcium signal and then to decipher this calcium signal in order to transduce the external information into cellular events (Haiech et al, 2011).…”

A etimologia de biomoléculas com metais de transição como auxiliar na aprendizagem de Química Biológica

“…16 A sua designação é adaptada de calmodulina, do inglês calmodulin (calcium-modulated protein), que é modulada pelo ião cálcio, a qual é mediadora de vários processos metabólicos. 17 No entanto, a estabilidade e a massa molecular das duas metalobiomoléculas são muito diferentes.…”