“…Although this uncoating is defined as the loss of HIV-1 capsid (CA) protein after the entry step, the nature and timing of the uncoating process is poorly understood (Arhel, 2010). The formation of the reverse transcription complex (RTC), in which reverse transcription from viral RNA to DNA takes place, accompanies the uncoating of infecting virion core (Warrilow et al, 2009;Arhel, 2010). Currently, little is known about the components of the RTC, although several studies have shown that matrix (MA), Vpr, RT, and IN are contained in the HIV-1 RTC (Fassati & Goff, 2001;McDonald et al, 2002;Iordanskiy et al, 2006).…”