Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder

Gibson, Benjamin C.; Vakhtin, Andrei A.; Clark, Vincent P.; Abbott, Christopher; Quinn, Davin K.

doi:10.3390/brainsci12010112

Cited by 13 publications

(12 citation statements)

References 162 publications

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“…Moreover, hemispheric asymmetry in negative emotion regulation has been observed. The intervention on right DLPFC resulted in a better effect than on the left, which may be due to the fact that negative emotional processing as occurring predominantly in the right hemisphere [ 94 ]. Meanwhile, we found that the effect of different return electrode placements should be considered regarding the effect of tDCS on the downregulation of negative emotions.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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(1) Background: Emotion regulation (ER) is regarded as a core treatment target for depression and other mental illnesses. In recent years, non-invasive brain stimulation (NIBS) has been extensively used as an intervention for mental illnesses, but there has been no systematic review conducted regarding its effect on emotion regulation. Therefore, we conducted a meta-analysis of the effectiveness of NIBS for emotion regulation; (2) Methods: Systematic searches were conducted in Embase, Web of Science, PubMed, and Cochrane Library. We analyzed the effects of NIBS on tasks assessing emotion regulation using a random-effects model, and further explored the moderating role of the following factors on transcranial direct current stimulation (tDCS) studies by conducting subgroup analyses and meta-regression: target electrode placement, return electrode placement, current intensity, target electrode size, and duration of intervention; (3) Results: A total of 17 studies were included. Our meta-analysis indicated a small but significant effect of NIBS on the downregulation of negative emotions. Separate analyses indicated that repetitive transcranial magnetic stimulation (rTMS) had a medium and significant effect on the downregulation of negative emotions, whereas tDCS had no significant effect. Subgroup analyses showed that the effect of tDCS was moderated by target and return electrode placemen; (4) Conclusions: These results indicate that NIBS had a positive effect on the downregulation of negative emotions. The stimulation protocols should be carefully considered and the underlying mechanisms should be further explored.

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Section: Discussionmentioning

confidence: 99%

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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“…41,42 During the emotion-inducing task, MDD patients showed decreased activity in the left frontal lobe and increased activity in the right frontal lobe. 43 Therefore, it is indicated that giving MDD patients left hemisphere excitatory stimulation appears to be more useful for improvements of symptoms.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS‐EEG and pilot study

Hao,

Dai,

Wei

et al. 2024

Photoderm Photoimm Photomed

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BackgroundMajor depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. An 820 nm tPBM can induce an increase in stimulated cortical excitability. The purpose of our study was to establish how clinical symptoms and time‐varying brain network connectivity of MDD were affected by transcranial photobiomodulation (tPBM).MethodsA total of 11 patients with MDD received 820 nm tPBM targeting the left FP for 14 consecutive days. The severity of symptoms was evaluated by neuropsychological assessments at baseline, after treatment, 4‐week and 8‐week follow‐up; 8‐min transcranial magnetic stimulation combined electroencephalography (TMS‐EEG) was performed for five healthy controls and five patients with MDD before and after treatment, and time‐varying EEG network was analyzed using the adaptive‐directed transfer function.ResultsAll of scales scores in the 11 patients decreased significantly after 14‐day tPBM (p < .01) and remained at 8‐week follow‐up. The time‐varying brain network analysis suggested that the brain regions with enhanced connection information outflow in MDD became gradually more similar to healthy controls after treatment.ConclusionsThis study showed that tPBM of the left FP could improve symptoms of patients with MDD and normalize the abnormal network connections.

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“…We found this necessary for two reasons. First, there is a large literature indicating differences among hemispheres in mood regulation 33 . Second, both the map reported by Siddiqi et al and the bilateral placement maps are highly symmetrical which could lead to a spurious overestimation of the results.…”

Section: Lateralitymentioning

confidence: 99%

Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

Deng,

Ousdal,

Oltedal

et al. 2023

Preprint

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Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this common causal network (CCN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis (Principal Component Analysis, PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CCN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CCN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes. This evidence further supports that treatment interventions converge on a CCN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.

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Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder

Cited by 13 publications

References 162 publications

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS‐EEG and pilot study

Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

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