Revisiting Coley’s Toxins: Immunogenic Cardiolipins from <i>Streptococcus pyogenes</i>

Shin, Yern-Hyerk; Bang, Sunghee; Park, Sung-Moo; Ma, Xiao; Cassilly, Chelsi; Graham, Daniel; Xavier, Ramnik; Clardy, Jon

doi:10.1021/jacs.3c07727

Cited by 7 publications

(7 citation statements)

References 33 publications

(86 reference statements)

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“…This stimulation led to a robust induction of TNF-α, signifying potential implications for immune regulation and cancer immunotherapy. 216 Research has shown that there is a close association between Streptococcus and the occurrence and development of head and neck cancer. 214 , 217 A recent study found that S. anginosus is elevated in patients with OSCC, highlighting the continued relevance of this bacterium in the carcinogenesis of the oral cavity.…”

Section: Overview Of Oral Microbiota In Carcinogenesismentioning

confidence: 99%

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Wang,

Sun,

Hua

et al. 2024

Int J Oral Sci

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Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via microbes. Nowadays, the role of oral microbes in the development and progression of cancer has received increasing scrutiny. At the same time, bioengineering technology and nanotechnology is growing rapidly, in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of cancers. These engineered bacteria were transformed to achieve directed genetic reprogramming, selective functional reorganization and precise control. In contrast to endotoxins produced by typical genetically modified bacteria, oral flora exhibits favorable biosafety characteristics. To outline the current cognitions upon oral microbes, engineered microbes and human cancers, related literatures were searched and reviewed based on the PubMed database. We focused on a number of oral microbes and related mechanisms associated with the tumor microenvironment, which involve in cancer occurrence and development. Whether engineering oral bacteria can be a possible application of cancer therapy is worth consideration. A deeper understanding of the relationship between engineered oral bacteria and cancer therapy may enhance our knowledge of tumor pathogenesis thus providing new insights and strategies for cancer prevention and treatment.

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Section: Overview Of Oral Microbiota In Carcinogenesismentioning

confidence: 99%

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Wang,

Sun,

Hua

et al. 2024

Int J Oral Sci

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“…Cancer immunotherapy heralds a promising revolution in the realm of oncological treatments. This groundbreaking approach, rooted in historical milestones like "Coley's toxins" [1] and, later, the identification of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), has consistently showcased the potential to redefine cancer treatment paradigms [2][3][4]. As we deepened our understanding of tumor antigens and immune-tumor interactions in the latter half of the 20th century, the emergence of agents targeting CTLA-4, programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1) pathways marked 2 of 18 significant successes in treating a range of malignancies [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Navigating the Immune Maze: Pioneering Strategies for Unshackling Cancer Immunotherapy Resistance

Yao,

Wang,

2023

Cancers

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Cancer immunotherapy has ushered in a transformative era in oncology, offering unprecedented promise and opportunities. Despite its remarkable breakthroughs, the field continues to grapple with the persistent challenge of treatment resistance. This resistance not only undermines the widespread efficacy of these pioneering treatments, but also underscores the pressing need for further research. Our exploration into the intricate realm of cancer immunotherapy resistance reveals various mechanisms at play, from primary and secondary resistance to the significant impact of genetic and epigenetic factors, as well as the crucial role of the tumor microenvironment (TME). Furthermore, we stress the importance of devising innovative strategies to counteract this resistance, such as employing combination therapies, tailoring immune checkpoints, and implementing real-time monitoring. By championing these state-of-the-art methods, we anticipate a paradigm that blends personalized healthcare with improved treatment options and is firmly committed to patient welfare. Through a comprehensive and multifaceted approach, we strive to tackle the challenges of resistance, aspiring to elevate cancer immunotherapy as a beacon of hope for patients around the world.

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“…[10,11] Diese Herausforderung wird noch deutlicher, wenn es sich um Lipide mikrobiellen Ursprungs handelt, da diese häufig bisher unbeschriebene strukturelle Veränderungen und hochspezifische Struktur-Aktivitäts-Profile aufweisen, [12][13][14] für die authentische Standards meist nicht verfügbar sind. [15][16][17] Die Vorhersagbarkeit von relativen Molekülstrukturen von Lipiden allein auf der Grundlage von MS-Daten ist daher meist noch zu unpräzise und kann zu lückenhaften oder fehlerhaften wissenschaftlichen Schlussfolgerungen führen.…”

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Strukturrevision einer weit verbreiteten marinen Sulfonolipidklasse basierend auf deren Isolierung und Totalsynthese

Roman,

Meisinger,

Guillonneau

et al. 2024

Angewandte Chemie

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The cosmopolitan marine Roseobacter clade is of global biogeochemical importance. Members of this clade produce sulfur‐containing amino lipids (SALs) of importance for biofilm formation and marine surface colonization processes. Despite their physiological importance and abundance, SALs have only been explored through genomic mining approaches and lipidomic studies based on mass spectrometry, which left the relative and absolute structures of SALs unresolved hindering progress in biochemical and functional investigations. Here, we report the structural revision of a new group of SALs, which we named cysteinolides, using a combination of analytical techniques, isolation and degradation experiments and total synthetic efforts. Contrary to the previously proposed homotaurine‐based structures, cysteinolides are composed of an N,O‐acylated cysteinolic acid‐containing head group carrying various different (α‑hydroxy) carboxylic acids. We performed the first validated targeted‐network based analysis, which allowed us to map the distribution and structural diversity of cysteinolides across bacterial lineages. Beyond offering structural insights, our research provides SAL standards and validated analytical data. This information holds significance for forthcoming investigations into bacterial sulfonolipid metabolism and biogeochemical nutrient cycling within marine environments.

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Revisiting Coley’s Toxins: Immunogenic Cardiolipins from Streptococcus pyogenes

Cited by 7 publications

References 33 publications

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Navigating the Immune Maze: Pioneering Strategies for Unshackling Cancer Immunotherapy Resistance

Strukturrevision einer weit verbreiteten marinen Sulfonolipidklasse basierend auf deren Isolierung und Totalsynthese

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