Revisiting Biginelli-like reactions: solvent effects, mechanisms, biological applications and correction of several literature reports
Pedro S. Beck,
Arthur G. Leitão,
Yasmin B. Santana
et al.
Abstract:This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
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