Revisiting an Old Concept in a New Era: 36 Hour Lung Preservation Using 10ºC Static Cold Storage

Gomes, Bruno; Wang, A.; Ribeiro, Rafaela Vanin Pinto; Galasso, M.; Hough, Olivia; Beronical, E.L.; Waddell, Thomas K.; Liu, M.; Andreazza, Ana Cristina; Keshavjee, S.; Cypel, Marcelo

doi:10.1016/j.healun.2020.01.1074

Cited by 2 publications

(1 citation statement)

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“…[90][91][92] Revisiting this concept, we showed that preserving lungs at 10°C improved preservation of cytoprotective metabolites, mitochondrial health, and preservation of cell membrane function. 93 Based on this result, we are currently conducting a clinical trial (identifier: NCT04616365) to investigate the safety and feasibility of semielective LTx with the use of 10°C storage, so that any lung retrieved after 10 p.m. may safely start the implantation after 6 a.m. which could be a remarkable transformation for the field of clinical LTx.…”

Section: Ongoing Studiesmentioning

confidence: 99%

Pushing the Envelope for Donor Lungs

Abdelnour‐Berchtold

Cypel

Keshavjee

2021

Semin Respir Crit Care Med

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The shortage of organ donors remains the major limiting factor in lung transplant, with the number of patients on the waiting list largely exceeding the number of available organ donors. Another issue is the low utilization rate seen in some types of donors. Therefore, novel strategies are continuously being explored to increase the donor pool. Advanced age, smoking history, positive serologies, and size mismatch are common criteria that decrease the rate of use when it comes to organ utilization. Questioning these limitations is one of the purposes of this review. Challenging these limitations by adapting novel donor management strategies could help to increase the rate of suitable lungs for transplantation while still maintaining good outcomes. A second goal is to present the latest advances in organ donation after controlled and uncontrolled cardiac death, and also on how to improve these lungs on ex vivo platforms for assessment and future specific therapies. Finally, pushing the limit of the donor envelope also means reviewing some of the recent improvements made in lung preservation itself, as well as upcoming experimental research fields. In summary, donor lung optimization refers to a global care strategy to increase the total numbers of available allografts, and preserve or improve organ quality without paying the price of early-, mid-, or long-term negative outcomes after transplantation.

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Section: Ongoing Studiesmentioning

confidence: 99%