Revisit the Practice of Lymph Node Biopsy in Patients Diagnosed as Ductal Carcinoma In Situ Before Operation: A Retrospective Analysis of 682 Cases and Evaluate the Role of Breast MRI

Lai, Hung-Wen; Chang, Yi-Lin; Chen, Shou‐Tung; Chang, Yuchun; Wu, Wen-Lan; Chen, Dar‐Ren; Kuo, Shou‐Jen

doi:10.21203/rs.3.rs-237060/v1

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…SLNB remains to this day the standard technique for staging the axillary cavity in patients with early-stage breast cancer [20][21][22][23]. It should be noted, despite a good lymph node collection, patients are still exposed to the risk of local or distant recurrence.…”

Section: Discussionmentioning

confidence: 99%

Effects of the number of removed lymph nodes on survival outcome in patients with sentinel node-negative breast cancer

Saputo¹

2022

Preprint

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Background: Sentinel lymph node biopsy is the gold standard surgical technique for axillary staging in patients with clinically node-negative. However, it is still uncertain what is the optimal number of sentinel lymph nodes (SLNs) to be removed to reduce the false-negative rate. The aim of this study was to investigate whether patients with a single negative SLN have a worse prognosis than those with two or more negative SLNs. Methods:A retrospective review was conducted on a large series of SLN-negative breast cancer patients. Survival outcomes and regional recurrence rate were evaluated according to the number of removed SLNs. Secondly, the contribution of different adjuvant therapies on disease-free survival was explored. Statistical analysis included the chisquare, Wilcoxon-Mann-Whitney test, and Kaplan-Meier survival analysis.Results: A total of 1080 patients were included in the study. A first group consisted of 328 patients in whom a single SLN was retrieved, and a second group consisted of 752 patients in whom two or more SLNs were retrieved. There was no relevant difference in median DFS (64.9 vs 41.4) for SLN = 1 vs SLN > 1 groups (HR 0.76, CI 95% 0.39-1.46; p = 0.38). A statistically significant difference in mDFS was showed only for HT-treated patients who were SLN = 1 if compared to SLN > 1 (100.6 months versus 35.3 months). Conclusions:There is likely a relationship between the number of resected SNL and mDFS. Our results, however, showed no relevant difference in median DFS for SLN = 1 vs SLN > 1 group, except for a subset of the patients treated with hormone therapy.

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Section: Discussionmentioning

confidence: 99%

Effects of the number of removed lymph nodes on survival outcome in patients with sentinel node-negative breast cancer

Saputo¹

2022

Preprint

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Rationality of sentinel node biopsy in the diagnosis and minimally invasive treatment of patients with breast cancer

Bukin¹,

Васин²,

Goloshchapova³

2023

Kreativnaâ hirurgiâ i onkologiâ

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Introduction. Sentinel node biopsy is the gold standard in the diagnosis of lymph node basin lesions in breast cancer. Although the method has got a long history of its application, some practical issues related to its economic and social advantages and disadvantages remain unresolved.Aims. To consider the efficiency of approaches to the diagnosis and minimally invasive treatment in breast cancer, following the experience of sentinel node biopsy in Regional Clinical Oncological Hospital, Yaroslavl.Materials and methods. Th e present paper involves the analysis of 942 histories of breast cancer patients who have undergone surgical treatment at Regional Clinical Oncological Hospital, Yaroslavl. According to the study results, 16% of stage I and II patients had a change in the initial status of lymph node basins aft er pathoanatomical examination of the removed lymph nodes. Th is prompted a change in preoperative examination and appointment of MRI of breast and lymph regional outflow for 64 patients prior to planning a sentinel lymph node biopsy.Results and discussion. Magnetic resonance imaging data correlated with the results obtained aft er histological examination and served to determine the extent of surgical treatment, reducing the risks of reintervention and locoregional recurrence.Conclusion. Sentinel node biopsy is a method that combines high informativity, safety and economic benefits. However, in order to achieve greater patient focus, a comprehensive approach to preoperative examination and principle of cooperation in the choice of treatment strategy should be observed in all cases.

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Revisit the Practice of Lymph Node Biopsy in Patients Diagnosed as Ductal Carcinoma In Situ Before Operation: A Retrospective Analysis of 682 Cases and Evaluate the Role of Breast MRI

Cited by 2 publications

References 31 publications

Effects of the number of removed lymph nodes on survival outcome in patients with sentinel node-negative breast cancer

Effects of the number of removed lymph nodes on survival outcome in patients with sentinel node-negative breast cancer

Rationality of sentinel node biopsy in the diagnosis and minimally invasive treatment of patients with breast cancer

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