Revision of Biological Methods for Determination of EDC Presence and Their Endocrine Potential

Abstract

Endocrine-disrupting compounds (EDC) are chemicals responsible for disturbances in the hormonal balance of organisms. This group of chemicals includes both egzogenic and endogenic substances or their mixtures that impact functioning of natural hormones in organisms. In the available literature one can find information on the application of chromatographic and related techniques in the analysis of environmental samples for detection, identification, and quantitation of a wide spectrum of chemicals posing endocrine properties. On the other hand, more and more biotests are being developed to determine endocrine potency of environmental samples due to development of genetic engineering methods and specific detection methods of cells' response to the action of particular chemicals of interest. This article presents revisions of the most novel methods for this potency determination with application to biological elements.

Risks and benefits related to alimentary exposure to xenoestrogens

“…In fact samples are often constituted by complicated matrices, where initially the compound of interest must be extracted from, then isolated, identified and quantified. Several analytical methods are nowadays available to detect estrogenic EDCs, depending on the nature of the sample to analyze (milk, meat, miscellaneous matrices, fish, packaging materials, etc) in a cost-effective way, and increasing efforts in finding more sensible and accurate analytical methods are currently underway (Adamusova et al, 2014; Capriotti et al, 2013; Wang et al, 2008; Kudlaka et al, 2015; Rotroff et al 2014). …”

Assessment of toxic and endocrine potential of substances migrating from selected toys and baby products

“…Furthermore, some of them can be found in the final product as unintended contamination. The majority of synthetic compounds listed above is characterized by elevated lipophilicity; thus, they can more easily permeate biological membranes and enter live cells and, as a result, bioaccumulate in various tissues and organs (Kudłak et al 2015a, b). This situation is made more serious by the fact that a vast majority of these compounds has properties similar to contamination from the EDC group (Endocrine Disrupting Compound; Li et al 2010; Kudłak et al 2015a).…”

Analysis and Bioanalysis: an Effective Tool for Data Collection of Environmental Conditions and Processes

“…Compounds responsible for interfering with the body's endocrine system are "exogenous substances or their mixtures influencing the function(s) of the endocrine system, thus inducing adverse effects in a given organism or its offspring or subpopulation" [14]. Chemical compounds responsible for interfering with the endocrine system (EDC) manifest their influence by [15] imitating endogenous hormones, antagonizing the synthesis of normal hormones or their metabolism, and modifying the level of hormonal receptors.…”

“…Fig. 5 presents information about the analytical tools that can be used to obtain the aforementioned types of analytical information [15].…”