Revising LH cut-off for the diagnosis of central precocious puberty via triptorelin stimulation assay
Paolo Cavarzere,
Marco Sandri,
Marta Arrigoni
et al.
Abstract:Introduction
Precocious puberty (PP) in girls is defined by thelarche before age 8. The diagnostic gold standard is an increased LH level following gonadotropin-releasing hormone (GnRH) stimulation. Alternatively, GnRH analogues like triptorelin can be used, though their interpretation varies. Since 2000, we have used a triptorelin-induced LH cut-off of 15 IU/L, 4 h post-stimulus. However, many girls showed LH values below this threshold despite evident pubertal progression.
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