Revised definition of predicted left ventricular mass using ambulatory blood pressure in healthy Korean adults

A high risk of local relapse is the main challenge of HER2+ breast cancer after breast-conserving surgery. We aimed to develop a long-acting delivery system for Herceptin, a HER2-targeting antibody, using injectable and thermosensitive hydrogels as the carrier to prevent the local relapse of HER2+ breast tumors while minimizing systemic side effects, especially cardiotoxicity.Methods: Two poly(lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymers with different PEG/PLGA proportions were synthesized. Their mixtures with rational mix proportions displayed sol-gel transitions in water with rising of temperature and the Herceptin-loaded hydrogel systems were then prepared. Both the in vivo antitumor and anti-relapse efficacies were evaluated after hypodermic injection of the Herceptin-loaded hydrogel, and the cardiotoxicity was also detected.Results: The gel performance, degradation rate and drug release kinetics of hydrogels were easily adjustable by simply varying the mix proportion. The hydrogel matrix with a specific mix proportion not only avoided initial burst release but also achieved sustained release of Herceptin in vitro for up to 80 days, which is the longest period of Herceptin delivery that has ever been reported. In vivo biodistribution studies performed in SK-BR-3 tumor-bearing mice revealed that a single hypodermic administration of the Herceptin-loaded hydrogel adjacent to the tumor tissue promoted the intratumoral antibody accumulation. This resulted in a better antitumor efficacy compared to weekly hypodermic injections of Herceptin solution for 28 days. A tumor relapse model was also established by imitative breast-conserving surgery on tumor-bearing mice, and both the single injection of the Herceptin-loaded hydrogel and the weekly injection of the Herceptin solution achieved superior anti-relapse efficacy. Furthermore, both antitumor and anti-relapse experiments demonstrated that the weekly pulsed administration of the Herceptin solution caused cardiotoxicity; however, the sustained release of Herceptin from the hydrogel effectively prevented this side effect.Conclusion: The Herceptin-loaded hydrogel has great potential for preventing the relapse of HER2+ breast tumors after breast-conserving surgery with enhanced therapeutic efficacy, improved patient compliance and significantly reduced side effects.

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“…where D is the left ventricular diameter 62, 63. Subsequently, all the nude mice were sacrificed, and the tumors were dissected and weighed.…”

Section: Methodsmentioning

confidence: 99%

Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery

et al. 2019

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Effect of obesity and blood pressure dipping status on left ventricular mass in normotensive young adults

Fitriani,

Bakri,

Kasim

et al. 2024

Ukr. J. Nephrol. Dial.

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Despite the established links between obesity, blood pressure variability, and cardiovascular risks, the specific impact of the interaction between obesity and non-dipping blood pressure status on left ventricular mass (LVM) in normotensive individuals remains underexplored. Most studies have focused on hypertensive populations, leaving a critical gap in understanding how these factors contribute to cardiovascular changes in normotensive young adults. This study aims to address this gap by examining the combined effects of obesity and blood pressure dipping status on LVM in a normotensive cohort of young subjects. Methods: This cross-sectional study was conducted at Hasanuddin University Hospital and Central General Hospital (RSUP) Dr. Wahidin Sudirohusodo from March 2023, with a sample of 63 subjects divided into 32 dippers and 31 non-dippers. Interviews and ambulatory blood pressure monitoring (ABPM) were used to collect blood pressure data and history of hypertension. LVM measurements were obtained via echocardiography. Data were analyzed using SPSS version 25, with statistical significance set at p<0.05. Results: LVM was significantly greater in males, obese individuals, and non-dippers compared to females, non-obese individuals, and dippers (178.2±141.6 g vs. 102.68±32.1 g; 156.3±124.3 g vs. 101.39±26.02 g; 150.5±118.6 g vs. 103.5±38.4 g with p=0.029, p=0.026, p=0.037, respectively). Both non-dipping status and obesity significantly affected LVM, with odds ratios of 4.27 and 3.31, respectively (p<0.05). Non-dipping status was the dominant factor affecting LVM, with the lowest risk observed in the dipping and non-obese group (OR=1.00). Conclusion: Obesity and non-dipping blood pressure status, and their interaction, increase LVM. It is necessary to control obesity in young adults even if they are normotensive.

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Revised definition of predicted left ventricular mass using ambulatory blood pressure in healthy Korean adults

Cited by 2 publications

References 19 publications

Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery

Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery

Effect of obesity and blood pressure dipping status on left ventricular mass in normotensive young adults

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