Revised classification of the subfamily Leishmaniinae (Trypanosomatidae)

Kostygov, Alexei Y.; Yurchenko, Vyacheslav

doi:10.14411/fp.2017.020

Cited by 56 publications

(65 citation statements)

References 24 publications

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“…For instance, a substitution of W for L within the catalytic triad at position 325 can apparently be tolerated and it does not affect the enzymatic activity, since G. max APX (with L 325 ) shows activity comparable to the A. thaliana orthologue (with W 325 ) [50,51]. Uniquely, APXs of L. major, L. seymouri, and N. esmeraldas (and, probably, other representatives of Leishmaniinae [52]) possess the N-terminal anchoring trans-membrane domain that modulates their catalytic activity. While full-length proteins exhibit specific APX activities comparable to the cytosolic counterparts, deletion of this domain from L. major caused a 5-fold decrease in activity [34].…”

Section: Discussionmentioning

confidence: 99%

Catalase and Ascorbate Peroxidase in Euglenozoan Protists

et al. 2020

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In this work, we studied the biochemical properties and evolutionary histories of catalase (CAT) and ascorbate peroxidase (APX), two central enzymes of reactive oxygen species detoxification, across the highly diverse clade Eugenozoa. This clade encompasses free-living phototrophic and heterotrophic flagellates, as well as obligate parasites of insects, vertebrates, and plants. We present evidence of several independent acquisitions of CAT by horizontal gene transfers and evolutionary novelties associated with the APX presence. We posit that Euglenozoa recruit these detoxifying enzymes for specific molecular tasks, such as photosynthesis in euglenids and membrane-bound peroxidase activity in kinetoplastids and some diplonemids.

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Section: Discussionmentioning

confidence: 99%

Catalase and Ascorbate Peroxidase in Euglenozoan Protists

et al. 2020

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“…Many hypotheses have been proposed to explain the gill arch preference by monogeneans on teleosts. Authors like Lo and Morand (2001) argued that the median arches are more infected because of the large volume of water flowing through them, while Buchmann (1989) and Koskivaara and Valtonen (1991) associated this preference to the large surface of colonization offered to parasites. Lo and Morand (2001) previously explained this phenomenon by parasite load which induces the competition and thus the gill selection.…”

Section: Discussionmentioning

confidence: 99%

“…Authors like Lo and Morand (2001) argued that the median arches are more infected because of the large volume of water flowing through them, while Buchmann (1989) and Koskivaara and Valtonen (1991) associated this preference to the large surface of colonization offered to parasites. Lo and Morand (2001) previously explained this phenomenon by parasite load which induces the competition and thus the gill selection. Koskivaara and Valtonen (1992) and Guttiérrez and Martorelli (1994) also suggested that the host immunity can influence the microhabitat selection.…”

Section: Discussionmentioning

confidence: 99%

Spatial distribution of monogenean gill parasites of Parachanna obscura (Günther, 1861) – Channidae – in Lake Ossa (Edéa, Cameroon)

Nack¹,

Mandeng²,

Yede³

et al. 2018

Int. J. Bio. Chem. Sci

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Parasites are a danger for fish even more in natural environment than in farming conditions. Knowledge of their biology of is important for prevention. The objective of this study was to investigate the distribution of monogenean gill community of Parachanna obscura (Pisces, Channidae). Monogenean species were identified using the morphology of haptoral and genital sclerotized parts. Appropriate statistical tests were used to compare prevalence and intensity of parasites. In Lake Ossa (south Cameroon), P. obscura individuals were in relatively good condition (K = 1,4±0,15) although they were infected by five monogenean species (Eutrianchoratus magnus, E. minutus, E. imbachi, E. chibami and E. malleus). Male and female fish harbor similar parasite intensity. There was not statistical difference in the infection patterns of different host sizes, although big or old fish seemed to accumulate parasites over time. The distribution of helminthes on the gills did not revealed host side preference. There is no evidence of competition between species of Eutrianchoratus in their distribution areas, but the filaments of different gill arches exert a progressive (antero-posterior) sifting effect on the infecting larvae. This study proves once again that in natural environment parasite intensities are very low or low and this state minimizes competition between monogeneans species.

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“…One of them included the gene under study along with the sequences identified in all other Leishmaniinae, whose genomes had been sequenced thus far, and those of the genus Strigomonas from the endosymbiont-harboring subfamily Strigomonadinae (Figure 1). Of note, all recognized subgenera of Leishmania (Leishmania, Viannia¸Sauroleishmania, and Mundinia [27,28]) were included in the analysis, but the homologous sequences of the L. (Viannia) species were pseudogenized. The three other clades composed a super-clade, which was sister to the first one.…”

Section: Lmxm220250 Encodes a Dual Specificity Phosphatase Lmdusp1mentioning

confidence: 99%

LmxM.22.0250-Encoded Dual Specificity Protein/Lipid Phosphatase Impairs Leishmania mexicana Virulence In Vitro

et al. 2019

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Protein phosphorylation/dephosphorylation is an important regulatory mechanism that controls many key physiological processes. Numerous pathogens successfully use kinases and phosphatases to internalize, replicate, and survive, modifying the host′s phosphorylation profile or signal transduction pathways. Multiple phosphatases and kinases from diverse bacterial pathogens have been implicated in human infections before. In this work, we have identified and characterized the dual specificity protein/lipid phosphatase LmDUSP1 as a novel virulence factor governing Leishmania mexicana infection. The LmDUSP1-encoding gene (LmxM.22.0250 in L. mexicana) has been acquired from bacteria via horizontal gene transfer. Importantly, its orthologues have been associated with virulence in several bacterial species, such as Mycobacterium tuberculosis and Listeria monocytogenes. Leishmania mexicana with ablated LmxM.22.0250 demonstrated severely attenuated virulence in the experimental infection of primary mouse macrophages, suggesting that this gene facilitates Leishmania pathogenicity in vertebrates. Despite significant upregulation of LmxM.22.0250 expression in metacyclic promastigotes, its ablation did not affect the ability of mutant cells to differentiate into virulent stages in insects. It remains to be further investigated which specific biochemical pathways involve LmDUSP1 and how this facilitates the parasite′s survival in the host. One of the interesting possibilities is that LmDUSP1 may target host′s substrate(s), thereby affecting its signal transduction pathways.

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Revised classification of the subfamily Leishmaniinae (Trypanosomatidae)

Cited by 56 publications

References 24 publications

Catalase and Ascorbate Peroxidase in Euglenozoan Protists

Catalase and Ascorbate Peroxidase in Euglenozoan Protists

Spatial distribution of monogenean gill parasites of Parachanna obscura (Günther, 1861) – Channidae – in Lake Ossa (Edéa, Cameroon)

LmxM.22.0250-Encoded Dual Specificity Protein/Lipid Phosphatase Impairs Leishmania mexicana Virulence In Vitro

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