Technologies for prevention of HIV and other sexually transmitted infections (STIs) have changed and improved over the last decade. Men having sex with men (MSM) are among the HIV target populations as well among the most vulnerable to HIV infection, therefore, from a combined prevention perspective, the use of post-exposure prophylaxis (PEP) in combination with other methods and prevention strategies is highly recommended. The scientific literature has limited qualitative studies in this segment on decision making regarding the use of combined prevention, more specifically of PEP. Taking into account the possible combinations of social markers, such as sexual orientation, gender, generation, race / ethnicity and social class, risk perceptions and vulnerability of MSM; the objective of this work is to understand the process of choosing the PEP strategy in the context of combined prevention programs of and the impact of its use on the affective-sexual experience of MSM. Two articles were written focusing on this subject, the first one is a synthesis thematic of literature, which is a qualitative review of prevention methods and methods among MSM. The text demonstrates the primacy of studies addressing some HIV prevention methods and strategies in the MSM group at the expense of others, and relevance of stigma issues and support networks in the effectiveness of surveyed prevention methods and strategies. The second article is a qualitative analysis of empirical material derived from interviews with 25 MSM using PEP in five Brazilian cities. The article investigates risk perceptions and the PEP use experience, contributing to the strengthening of the discussion on the stigma impacts and the great potential of the support networks for combined prevention as a whole. The two common findings, stigma and support networks, are shown as key pieces to understand and act in prevention with the MSM population, bringing even more theoretical elements to the discussion on combined HIV prevention.