Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis

Pucheu‐Haston, Cherie M.; Bizikova, Petra; Eisenschenk, Melissa; Santoro, Domenico; Nuttall, Tim; Marsella, Rosanna

doi:10.1111/vde.12201

Cited by 43 publications

(43 citation statements)

References 110 publications

(159 reference statements)

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“…Neutered females had a much greater risk than the other sex categories indicating a strong suppressive effect of estrogens on the expression of the disease. Atopic dermatitis involves the production of IgE or IgGd, a subset of IgG antibodies, in response to antigens in the environment with IgE being viewed as more diagnostic and implicated in causality though there exists conflicting reports on the latter [75–77]. …”

Section: Discussionmentioning

confidence: 99%

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

et al. 2016

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BackgroundGonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for structural disorders and some neoplasias. The relation between neuter status and autoimmune diseases has not been explored. This study evaluated the prevalence and risk of atopic dermatitis (ATOP), autoimmune hemolytic anemia (AIHA), canine myasthenia gravis (CMG), colitis (COL), hypoadrenocorticism (ADD), hypothyroidism (HYPO), immune-mediated polyarthritis (IMPA), immune-mediated thrombocytopenia (ITP), inflammatory bowel disease (IBD), lupus erythematosus (LUP), and pemphigus complex (PEMC), for intact females, intact males, neutered females, and neutered males. Pyometra (PYO) was evaluated as a control condition.ResultsPatient records (90,090) from the William R. Pritchard Veterinary Medical Teaching Hospital at the University of California, Davis from 1995 to 2010 were analyzed in order to determine the risk of immune-mediated disease relative to neuter status in dogs. Neutered dogs had a significantly greater risk of ATOP, AIHA, ADD, HYPO, ITP, and IBD than intact dogs with neutered females being at greater risk than neutered males for all but AIHA and ADD. Neutered females, but not males, had a significantly greater risk of LUP than intact females. Pyometra was a greater risk for intact females.ConclusionsThe data underscore the importance of sex steroids on immune function emphasizing a role of these hormones on tissue self-recognition. Neutering is critically important for population control, reduction of reproductive disorders, and offers convenience for owners. Despite these advantages, the analyses of the present study suggest that neutering is associated with increased risk for certain autoimmune disorders and underscore the need for owners to consult with their veterinary practitioner prior to neutering to evaluate possible benefits and risks associated with such a procedure.

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Section: Discussionmentioning

confidence: 99%

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

et al. 2016

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“…The allergy is mostly directed against environmental allergens though food allergens might contribute to the disease (Chesney 2002, Olivry and others 2007a). In most, but not all dogs, IgE antibodies against those allergens can be found (Pucheu-Haston and others 2015a). …”

Section: Introductionmentioning

confidence: 99%

“…Allergen testing and extracts are costly (Saridomichelakis and Olivry 2016). Furthermore, there is a subset of dogs not showing positive test reactions excluding them from this treatment option (Pucheu-Haston and others 2015a). In addition, it may take several months before clinical improvement is seen and up to half of the patients may fail to respond to AIT (Zur and others 2002, Loewenstein and Mueller 2009).…”

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of cytosine‐phosphate‐guanine oligodeoxynucleotides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis

Wagner¹,

Geh²,

Hubert³

et al. 2017

Veterinary Record

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Cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) are a promising new immunotherapeutic treatment option for canine atopic dermatitis (AD). The aim of this uncontrolled pilot study was to evaluate clinical and immunological effects of gelatine nanoparticle (GNP)-bound CpG ODN (CpG GNP) on atopic dogs. Eighteen dogs with AD were treated for 8 weeks (group 1, n=8) or 18 weeks (group 2, n=10). Before inclusion and after 2 weeks, 4 weeks, 6 weeks (group 1+2), 8 weeks, 12 weeks and 16 weeks (group 2) 75 µg CpG ODN/dog (bound to 1.5 mg GNP) were injected subcutaneously. Pruritus was evaluated daily by the owner. Lesions were evaluated and serum concentrations and mRNA expressions of interferon-γ, tumour necrosis factor-α, transforming growth factor-β, interleukin (IL) 10 and IL-4 (only mRNA expression) were determined at inclusion and after 8 weeks (group 1+2) and 18 weeks (group 2). Lesions and pruritus improved significantly from baseline to week 8. Mean improvements from baseline to week 18 were 23 per cent and 44 per cent for lesions and pruritus, respectively, an improvement of ≥50 per cent was seen in six out of nine and three out of six dogs, respectively. IL-4 mRNA expression decreased significantly. The results of this study show a clinical improvement of canine AD with CpG GNP comparable to allergen immunotherapy. Controlled studies are needed to confirm these findings.

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“…In addition, the occurrence in a predisposed breed and the onset at young age enhance the possibility of AD [791523]. Interestingly, evidence suggests that dogs also have a predisposition to develop clinical signs compatible with AD triggered by food antigens [1520]. Therefore, certain dogs with food-induced AD (FIAD) and non-food-induced AD (NFIAD) cannot be differentiated on a clinical basis.…”

Section: Introductionmentioning

confidence: 99%

Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial

Hsiao¹,

Chen²,

Willemse

2016

J Vet Sci

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This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups. These findings indicated that cetirizine (and likely H1 histamine receptor antagonists in general) should not be recommended for the control of pruritus in dogs with long term allergies.

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Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis

Cited by 43 publications

References 110 publications

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

Preliminary evaluation of cytosine‐phosphate‐guanine oligodeoxynucleotides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis

Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial

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