Review: The Oxidant/Antioxidant Balance During Regular Low Density Lipoprotein Apheresis

Schettler, Volker; Methe, Heiko; Staschinsky, Dirk; Schuff‐Werner, P.; Müller, Gerhard A.; Wieland, Eberhard

doi:10.1111/j.1091-6660.1999.t01-3-.x

Cited by 41 publications

(31 citation statements)

References 61 publications

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“…MDA is a lipid peroxidation product, the levels of which reflect the degree of tissue oxidative damage. 18) In this study, FNS reduced the stimulatory effects of MI on MDA content. TAOC and SOD reflect the ability to protect against OFR system.…”

Section: Discussionsupporting

confidence: 49%

Preventive Effect of Fastigial Nucleus on Oxidative Damage in Rats Undergoing Acute Myocardial Infarction

Wei

Zhang

2008

JOURNAL OF HEALTH SCIENCE

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The fastigial nucleus (FN) plays an important role in regulating cardiovascular, respiratory, and visceral activities. We investigated the effect and mechanism of FN stimulation (FNS) on the prevention of oxidative damage in wistar rats undergoing surgically induced acute myocardial infarction (AMI). The FN lesion (FNL) group was subjected to bilateral FN lesioning before the nucleus was electrically stimulated and AMI was induced. FN of AMI rats were electrically stimulated as the FNS and AMI group. Sham-stimulated and sham-operated rats were randomly selected in one group as control. We measured lactic dehydrogenase (LDH) and creatine phosphokinase (CK) activity, as well as myocardial infarction (MI) size. Malondialdehyde (MDA) content, total anti-oxidative capability (TAOC) and superoxide dismutese (SOD) activity in myocardium were also measured. FNS lowered the activities of LDH and CK in comparison to the AMI group. Infarct size was less in FNS-treated rats. The AMI group had elevated MDA levels compared with sham-treated animals. TAOC and SOD activities were decreased in the AMI group; there was attenuation of MDA and increases of TAOC and SOD activities in the FNS group (p < 0.01). We conclude that FNS can reduce damage during MI. The mechanism of the protective effect might be partially related to its antioxidative role.

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Section: Discussionsupporting

confidence: 49%

Preventive Effect of Fastigial Nucleus on Oxidative Damage in Rats Undergoing Acute Myocardial Infarction

Wei

Zhang

2008

JOURNAL OF HEALTH SCIENCE

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“…However, according to observation of Schettler et al (48) no difference between hyperlipidemic patients undergoing LDL-apheresis and coronary heart disease patients not undergoing extracorporeal treatment was confirmed. Nevertheless, an increased concentration in both patients groups has been claimed (48).…”

Section: Discussionmentioning

confidence: 90%

“…Oxidation of LDL and the formation of lipid hydroperoxides are now widely accepted as a crucial step in atherogenesis. One important decomposition product of lipid hydroperoxides is MDA, which is derived from unsaturated fatty acids carrying more than two double bounds (47,48). However, according to observation of Schettler et al (48) no difference between hyperlipidemic patients undergoing LDL-apheresis and coronary heart disease patients not undergoing extracorporeal treatment was confirmed.…”

Section: Discussionmentioning

confidence: 98%

“…One important decomposition product of lipid hydroperoxides is MDA, which is derived from unsaturated fatty acids carrying more than two double bounds (47,48). However, according to observation of Schettler et al (48) no difference between hyperlipidemic patients undergoing LDL-apheresis and coronary heart disease patients not undergoing extracorporeal treatment was confirmed. Nevertheless, an increased concentration in both patients groups has been claimed (48).…”

Section: Discussionmentioning

confidence: 98%

“…SOD seems to be the first line of defence against oxygen radicals generated by phagocytes. Schettler et al (48) suppose that no critical concentration of oxygen radicals is achieved during LDL-apheresis process, since SOD activity is not affected. GPx is a selenoprotein that reduces lipid and other organic hyperperoxides including peroxide.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E

Solichová

Bláha

Aufartová

et al. 2015

J Nutr Sci Vitaminol

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A complete change in lifestyle, a strict diet and intensive combined pharmacotherapy (HMG CoA reductase inhibitors are the most important components) are necessary for patients with familial hypercholesterolemia (FH) and provide excellent results in most patients. Unfortunately, these measures are not sufficient for all patients (1-6). Homozygous FH patients usually fail to show any response to pharmacotherapy. LDL-apheresis has become the standard treatment for individuals homozygous for FH (7-9). In homozygous FH, statins provide a range of responses, decreasing the plasma LDL anywhere from 0% to 48%, with an average of approximately 15% for receptor-negative individuals and approximately 26% for receptor-defective individuals (5). LDL-apheresis could be offered to treat symptomatic coronary heart disease in individuals who are heterozygous FH and whose LDL remains high (.160 mg/ dL, 4.2 mmol/L) or decreases by ,40% in response to maximal medical treatment (1).Term LDL-apheresis was originally used in 1981 by Stoffel et al. (10) as an immunoadsorption elimination extracorporeal method (10). Nowadays, "LDL-apheresis" or "lipoprotein apheresis" is used for all types of extracorporeal eliminations of cholesterol. In our study we used a modification of the Stoffel and Borberg LDLapheresis-immunoadsorption method and also double filtration plasmapheresis (the primary filter is replaced by a centrifugal separator), which additionally eliminates fibrinogen and has an influence on rheological properties. For our study we will use for the first mentioned method the term "LDL-apheresis" and for the second mentioned method the term "rheohaemapheresis."LDL-apheresis is an invasive and relatively expensive but safe procedure (11, 12); it decreases cholesterol radically but it is also troubling to the patient's standard AS CR v.v.i., Olomouc, Czech Republic (Received June 26, 2014) Summary Lipid apheresis (extracorporeal lipoprotein elimination) is administered to patients with familial hypercholesterolemia who fail to respond to standard therapy. The nature of the treatment process raises the suspicion that it decreases not only cholesterol but also antioxidants. A group of 12 patients (average age 47617 y, 4 homozygous and 8 heterozygous individuals) with familial hypercholesterolemia treated by LDL-apheresis or rheohaemapheresis for 3-12 y was included in the study. In addition to cholesterol and triacylglycerol levels, vitamin E and vitamin A and also other markers of antioxidant activity were investigated. Nevertheless, the most important determined parameter was the vitamin E/cholesterol ratio in serum and lipoproteins. The results indicate that both extracorporeal elimination methods are effective and suitable ways to treat severe familial hypercholesterolemia, as the LDL fraction of cholesterol decreased by approximately 77% and 66% following LDL-apheresis and rheohaemapheresis, respectively. In addition, the serum vitamin E decreased by 54% and 57% and the decrease of the serum vitamin A was approximately 20%...

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Dapoxetine prevents neuronal damage and improves functional outcomes in a model of ischemic stroke through the modulation of inflammation and oxidative stress

Abdel-Hameed,

El-Daly,

Ahmed

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Stroke is a medical emergency that is associated with substantial mortality and functional disability in adults. The most popular class of antidepressants, selective serotonin reuptake inhibitors SSRIs, have recently been shown in studies to have positive effects on post-stroke motor and cognitive function. Thus, we hypothesized that dapoxetine (DAP), a short-acting SSRI, would be effective against cerebral ischemia/reperfusion injury. Adult male Wister rats (200–250 g) were subjected to a sham operation or bilateral common carotid artery occlusion (BCCAO) for 30 min followed by 24 h of reperfusion to induce global cerebral ischemia/reperfusion (I/R) injury. Rats were treated with vehicle or DAP (30 or 60 mg/kg, i.p.) 1 h before BCCAO. The neurobehavioral performance of rats was assessed. The infarct volume, histopathological changes, oxidative stress parameters, and apoptotic and inflammatory mediators were determined in the brain tissues of euthanized rats. Our results confirmed that DAP significantly ameliorated cerebral I/R-induced neurobehavioral deficits, reduced cerebral infarct volume, and histopathological damage. Moreover, DAP pretreatment reduced lipid peroxidation, caspase-3, and inflammatory mediators (TNF-α and iNOS) compared to I/R-injured rats. Thus, DAP pretreatment potentially improves neurological function, and cerebral damage in cerebral ischemic rats may be partly related to the reduction in the inflammatory response, preservation of oxidative balance, and suppression of cell apoptosis in brain tissues.

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Review: The Oxidant/Antioxidant Balance During Regular Low Density Lipoprotein Apheresis

Abstract: Low density lipoprotein (LDL) apheresis is a safe procedure to treat severe hypercholestrolemia in pa-

Cited by 41 publications

References 61 publications

Preventive Effect of Fastigial Nucleus on Oxidative Damage in Rats Undergoing Acute Myocardial Infarction

Preventive Effect of Fastigial Nucleus on Oxidative Damage in Rats Undergoing Acute Myocardial Infarction

The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E

Dapoxetine prevents neuronal damage and improves functional outcomes in a model of ischemic stroke through the modulation of inflammation and oxidative stress

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