Review Structure, function, and localization of aquaporins: their possible implications on gamete cryopreservation

Sales, A.D.; Lobo, Carlos Henrique; Carvalho, Adonias Almeida; Moura, Arlindo A.; Rodrigues, Ana Paula Ribeiro

doi:10.4238/2013.december.13.5

Cited by 44 publications

(33 citation statements)

References 58 publications

(86 reference statements)

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“…Moreover, this AQP was present in the granulosa and theca cells of follicular wall throughout the period of development until ovulation. Thus, this finding implies a possible involvement of AQP4 in folliculogenesis in the hen ovary similarly as it was strongly suggested for AQPs in mammalian ovaries (Grzesiak et al, 2016;McConnell et al, 2002;Sales, Lobo, Carvalho, Moura, & Rodrigues, 2013;Skowronska, Mlotkowska, Eliszewski, Nielsen, & Skowronski, 2015;Starowicz et al, 2014;Sun et al, 2007Sun et al, , 2009). These results, obtained for the first time in birds, are consistent with those previously reported in the human (Thoroddsen et al, 2011) and bovine (Williams, 2012) ovary, and extend the number of avian tissues in which presence of AQP4 has been shown, that is, the brain-a main place of AQP4 presence, proventriculus, muscle, kidney, ureter and testis (Goren, Adorján, & Kálmán, 2006;Nishimura & Yang, 2013;Saito, Ikegami, & Shimada, 2005;Skowronski, Leska, Robak, & Nielsen, 2009;Sugiura, Aste, Fujii, Shimada, & Saito, 2008;Yoshimura et al, 2011).…”

Section: Discussionsupporting

confidence: 79%

Expression of aquaporin 4 in the chicken ovary in relation to follicle development

Nowak

Grzesiak

Sakai

et al. 2017

Reprod Domestic Animals

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In the mammalian ovary, aquaporins (AQPs) are thought to be involved in the regulation of fluid transport within the follicular wall and antrum formation. Data concerning the AQPs in the avian ovary is very limited. Therefore, the present study was designed to examine whether the AQP4 is present in the chicken ovary, and if so, what is its distribution in the ovarian compartment of the laying hen. Localization of AQP4 in the ovarian follicles at different stage of development was also investigated. After decapitation of hens the stroma with primordial follicles and white (1-4 mm), yellowish (4-8 mm), small yellow and the three largest yellow pre-ovulatory follicles F3-F1 (F3 < F2 < F1; 20-36 mm) were isolated from the ovary. The granulosa and theca layers were separated from the pre-ovulatory follicles. The AQP4 mRNA and protein were detected in all examined ovarian compartments by the real-time PCR and Western blot analyses, respectively. The relative expression of AQP4 was depended on follicular size and the layer of follicular wall. It was the lowest in the granulosa layer of pre-ovulatory follicles and the highest in the ovarian stroma as well as white and yellowish follicles. Along with approaching of the largest follicle to ovulation the gradual decrease in AQP4 protein level in the granulosa layer was observed. Immunoreactivity for AQP4 was present in the granulosa and theca cells (theca interna ≥ theca externa > granulosa). The obtained results suggest that AQP4 may take part in the regulation of water transport required for follicle development in the chicken ovary.

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Section: Discussionsupporting

confidence: 79%

Expression of aquaporin 4 in the chicken ovary in relation to follicle development

Nowak

Grzesiak

Sakai

et al. 2017

Reprod Domestic Animals

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“…The basic structural difference between orthodox AQPs and GLPs is their pore size. Whereas the diameter of the pore is of 2.8 Å in the case of orthodox AQPs, it measures 3.4 Å in that of GLPs (reviewed by Sales, Lobo, Carvalho, Moura, & Rodrigues, ).…”

Section: Aquaporins: Ubiquitous Proteins In Live Organismsmentioning

confidence: 99%

Aquaporins in the male reproductive tract and sperm: Functional implications and cryobiology

Yeste

Morató

Rodríguez-Gil

et al. 2017

Reprod Domestic Animals

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Contents Aquaporins (AQPs) play a vital role for the transport of water and solutes across cell membranes. Classification of these ubiquitous proteins into three categories (orthodox AQPs, aquaglyceroporins and superaquaporins) is based on their sequence similarity and substrate selectivity. In the male reproductive tract of mammals, most AQPs (except AQP6 and AQP12) are found in different organs (including testis, efferent ducts and epididymis). AQP1 and AQP9 are the most abundant AQPs in the efferent ducts and epididymis and play a crucial role for the secretion/reabsorption dynamics of luminal fluid during sperm transport and maturation. AQP3, AQP7, AQP8 and AQP11 are the most abundant AQPs in sperm and are involved in the regulation of their volume, which is required for the differentiation of spermatids into spermatozoa during spermatogenesis, as well as in sperm transit along environments of different osmolality (male and female reproductive tracts). While different studies conducted in oocytes and embryos have demonstrated that AQPs are important for cryotolerance, data in sperm are scarce. At present, mounting evidence indicates that AQP3, AQP7 and AQP11 are involved in the sperm response to variations of osmolality and to freeze‐thawing procedures. All these studies contribute to understand the physiology of both male reproductive tract and sperm, and open up new research ventures on the improvement of sperm cryopreservation protocols.

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“…AQP-1 is the most commonly expressed isoform (Denker et al 1988) and its expression has been reported in kidneys, lungs, red blood cells, brain, and uterus. This subunit participates in H 2 O reabsorption and secretion across the secretory epithelia (Sales et al 2013). Uterine AQP-1 was found to be distributed in stromal vasculature and was up-regulated by estrogen (Li et al 1997).…”

Section: Introductionmentioning

confidence: 97%

Testosterone Induces Increase in Aquaporin (AQP)-1, 5, and 7 Expressions in the Uteri of Ovariectomized Rats

et al. 2015

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Testosterone has been reported to cause a decrease in uterine fluid volume in which this could involve the aquaporins (AQPs). This study aimed to investigate effect of testosterone on uterine AQP-1, 5, and 7 expressions in order to explain the reported reduction in uterine fluid volume under testosterone influence. Ovariectomized adult female rats received peanut oil, testosterone (1 mg/kg/day), estrogen (0.2 µg/kg/day), or combined estrogen plus testosterone for three consecutive days. Other groups received 3 days estrogen followed by 2 days either peanut oil or testosterone with or without flutamide or finasteride. A day after last injection, uteri were harvested, and the levels of AQP-1, 5, and 7 messenger RNA (mRNA) in uterine tissue homogenates were analyzed by real-time PCR (qPCR). Distributions of AQP-1, 5, and 7 proteins in uterus were observed by immunofluorescence. Levels of AQP-1 mRNA were elevated in rats receiving either estrogen or testosterone-only treatment; however, levels of AQP-5 and 7 mRNAs were elevated in rats receiving testosterone-only treatment. In rats pre-treated with estrogen, testosterone treatment resulted in higher AQP-1, 5, and 7 mRNA levels compared to vehicle treatment. Testosterone effects were antagonized by flutamide but not finasteride. Immunofluorescence study showed that AQP-1 was highly distributed in uterine lumenal epithelium following estrogen or testosterone-only treatment. However, AQP-5 and 7 distributions were high in uterine lumenal epithelium following testosterone-only treatment. Testosterone-induced up-regulation of AQP-1, 5, and 7 expressions in uterus could explain the observed reduction in uterine fluid volume as reported under this condition.

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Review Structure, function, and localization of aquaporins: their possible implications on gamete cryopreservation

Cited by 44 publications

References 58 publications

Expression of aquaporin 4 in the chicken ovary in relation to follicle development

Expression of aquaporin 4 in the chicken ovary in relation to follicle development

Aquaporins in the male reproductive tract and sperm: Functional implications and cryobiology

Testosterone Induces Increase in Aquaporin (AQP)-1, 5, and 7 Expressions in the Uteri of Ovariectomized Rats

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