Review: Protein O-GlcNAcylation regulates DNA damage response: A novel target for cancer therapy

Zhu, Zhuang; Li, Shaoming; Yin, Xiaopeng; Sun, Kai; Song, Jianzhong; Ren, Wenhao; Gao, Ling; Zhi, Keqian

doi:10.1016/j.ijbiomac.2024.130351

Cited by 2 publications

(1 citation statement)

References 175 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unspecified alterations in the patterns of O-GlcNAcylation on affected proteins could lead to severe side effects or new conditions. In addition, their high toxicity, low efficiency, low water solubility and cell permeability make in vivo studies difficult [ 128 , 129 ].…”

Section: The Promising Role Of O-glcnacylation In the Treatment Of Bo...mentioning

confidence: 99%

O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

Yan,

Zheng,

Ren

et al. 2024

Cell Commun Signal

Self Cite

View full text Add to dashboard Cite

O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by the activity of two enzymes, O-GlcNAc transferase (OGT) and O‑GlcNAcase (OGA). While OGT attaches O-GlcNAc to proteins, OGA removes O-GlcNAc from proteins. Since its discovery, researchers have demonstrated O-GlcNAcylation on thousands of proteins implicated in numerous different biological processes. Moreover, dysregulation of O-GlcNAcylation has been associated with several pathologies, including cancers, ischemia-reperfusion injury, and neurodegenerative diseases. In this review, we focus on progress in our understanding of the role of O-GlcNAcylation in bone pathophysiology, and we discuss the potential molecular mechanisms of O-GlcNAcylation modulation of bone-related diseases. In addition, we explore significant advances in the identification of O-GlcNAcylation-related regulators as potential therapeutic targets, providing novel therapeutic strategies for the treatment of bone-related disorders.

show abstract

Section: The Promising Role Of O-glcnacylation In the Treatment Of Bo...mentioning

confidence: 99%

O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

Yan,

Zheng,

Ren

et al. 2024

Cell Commun Signal

Self Cite

View full text Add to dashboard Cite

show abstract

Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma

Zhou,

Hang,

Wang

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Post-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, and nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development and progression, especially in hepatocellular carcinoma (HCC). This review outlines the role of O-GlcNAcylation in the development and progression of HCC. Moreover, we delve into the underlying mechanisms of O-GlcNAcylation in HCC and highlight compounds that target O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) to improve treatment outcomes. Understanding the role of O-GlcNAcylation in HCC will offer insights into potential therapeutic strategies targeting OGT and OGA, which could improve treatment for patients with HCC.

show abstract

Review: Protein O-GlcNAcylation regulates DNA damage response: A novel target for cancer therapy

Cited by 2 publications

References 175 publications

O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology

Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma

Contact Info

Product

Resources

About