Review: Pathogenesis of Parvovirus Infections in Children

Beers-Tas, MH van; Heidema, Jojanneke

doi:10.4172/2161-0517.1000110

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…First, somewhat unexpectedly, there were positive natural controls for B19 DNA. As Cossart et al suggest, the presence of viral DNA in healthy blood donors (28) can last for a long period despite the absence of clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

Parvovirus infection in systemic lupus erythematous patients in Najaf governorate, Iraq

Mahmood¹,

Abbas²,

Yasir³

et al. 2021

ASRO

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Background: The emergence of symptoms is consistent with systemic autoimmune diseases in relation to many viral infections, especially parvovirus B19 (PVB19).This study was conducted to investigate the IgM and IgG antibodies, in addition to the DNA of PVB19 in systemic lupus erythematosus (SLE) patients, and its relationship to disease activity, depending on the evolution of the age and immune status of the host. Aim of the study: Determination of PVB19 infection by different biomarkers in SLE patients in different age groups and genders. Methods: Serum samples were collected from 62 patients with SLE and 62 normal controls, in order to test for the PVB19 infection by detection of anti PVB19 IgM and IgG, and viral DNA, using ELISA and PCR, respectively. Results: The ELISA tests for IgM antibodies showed 21(33.9%) seropositive in 62 patients, and for IgG29 (46.8%) seropositive have been found. Out of 62 samples, 18 samples showed positive results for viral DNA. In the control group, 4(6.5%) IgM, 8(12.9%) IgG and 1(1.6%) positive viral DNA,have been found. These data were significantly different in SLE patients, compared with the healthy controls (P< 0.05). Conclusions: Viral infections, particularlyPVB19,are one of the most important infections associated with autoimmune diseases. We could not find any significant correlation between the emergence of PVB19 and SLE in affected patients, in terms of age groups and genders.

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Section: Discussionmentioning

confidence: 99%