“…Another possibility has been raised correlating autoimmune disease with trisomy-21 (Mellon, Pay, and Green, 1963;Fialkow, 1966). Graves' disease is frequently associated with longacting thyroid stimulator, an immunoglobulin (McKenzie, 1965;Beall and Solomon, 1966;Carneiro, Dorrington, and Munro, 1966 …”