Review Paper: The Challenge of Emerging Zoonoses in Asia Pacific

Bhatia, Rajesh; Narain, Jai Prakash

doi:10.1177/1010539510370908

Cited by 31 publications

(32 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ironically, the drug-resistant strains became widespread due to the misuse of antibiotics. This arsenal of drug-resistant strains is resistant to most available antibiotics [26–28], thus lead to severe morbidity and mortality of the patients.…”

Section: Introductionmentioning

confidence: 99%

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

El‐Kalyoubi

Fayed

Abdel‐Razek

2017

Chemistry Central Journal

View full text Add to dashboard Cite

BackgroundUracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum activities including anticancer, antiviral as well as antimicrobial activities.ResultsA newly synthesized compounds pyrimido[4,5-b][1, 4]diazepines 5a–e, 6a–d, lumazines 7a–d, triazolo[4,5-d]pyrimidine 8 and xanthines 9, 10 was prepared in a good yields. The antimicrobial and antioxidant activities of compounds 5a, 5b, 6a, 6d and 8 exhibited a wide range activity against the pathogenic tested microbes (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans, and Saccharomyces cerevisiae). Compound 8 showed activity against the fungus Aspergillus niger. The highest antioxidant activity was noticed for compound 5a.ConclusionsA series of novel pyrimido[4,5-b][1, 4]diazepines 5a–e, 6a–d, lumazines 7a–d, triazolo[4,5-d]pyrimidine 8 and xanthines 9, 10 was prepared from 5,6-diamino-1-(2-chlorobenzyl)uracil 3 in good yields. Compounds 5a–e, 6a–d were prepared by sequential manipulation of 3 with α,β-unsaturated ketones. Lumazines 7a–d were obtained from 3 by treatment with phenacyl bromides in the presence of TEA. Compound 8 was prepared by treatment of 3 with HNO2, while xanthines 9, 10 were obtained from 3 by consecutive acetylation then intramolecular cyclodehydration or heating with malononitrile under solvent-free condition. The antimicrobial and antioxidant activity of this series was evaluated in vitro and they showed either weak or moderate activities.Graphical abstractSeveral pyrimido[4,5-b][1,4]diazepines, lumazines, triazolo-, and imidazolopyrimidines were synthesized from the starting compound 4,5-diaminouracils. The newly synthesized compounds were screened for both antimicrobial and antioxidant activities.

show abstract

Section: Introductionmentioning

confidence: 99%

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

El‐Kalyoubi

Fayed

Abdel‐Razek

2017

Chemistry Central Journal

View full text Add to dashboard Cite

show abstract

“…There is evidence suggesting that risks from emerging and re-emerging diseases have increased as a result of intensified population mobility, population density, environmental degradation, socioeconomic inequalities and changing lifestyles. For example, closer human habitation near domesticated and wild animal populations has resulted in increased risks from zoonoses (Bhatia and Narain 2010). Around 60% of human pathogens are zoonotic, with more than 800 pathogens identified to date as causing zoonoses.…”

Section: Changing Health Needs In the Asia And The Pacific Regionmentioning

confidence: 99%

Health Policy inAsia and thePacific: Navigating Local Needs and Global Challenges

Lee

2013

Asia & Pacific Policy Stud

View full text Add to dashboard Cite

Asia and the Pacific are undergoing a remarkable economic transformation which is occurring at an exceptional pace. There is clear evidence of an equally rapid epidemiological transition in the region. This paper sets out the policy challenges of building healthy societies in the context of rapid economic change. The region’s location at the crossroads of contemporary globalization, resulting in intensified population mobility, large-scale trade and investment, and pressures to take collective action on shared problems, adds to the complexity of this task. The paper argues that health is integral to building stable and sustainable societies, and that there are opportunities to develop more holistic approaches that bring together hitherto separate policy spheres.

show abstract

“…The coming together of these factors, it is believed, is causing the region to be the epicentre of emerging and re-emerging zoonoses. As Bhatia and Narain (2010) write, "Asia is now widely believed to be the epicentre of some of the most important infectious diseases that are of stupendous global public health importance." Two of three influenza pandemics which occurred during the twentieth century originated in Asia.…”

Section: Changing Health Needs In the Asia And The Pacific Regionmentioning

confidence: 99%

Health Policy in Asia and the Pacific: Navigating Local Needs and Global Challenges

Lee

2013

SSRN Journal

View full text Add to dashboard Cite

Asia and the Pacific are undergoing a remarkable economic transformation which is occurring at an exceptional pace. There is clear evidence of an equally rapid epidemiological transition in the region. This paper sets out the policy challenges of building healthy societies in the context of rapid economic change. The region's location at the crossroads of contemporary globalization, resulting in intensified population mobility, large-scale trade and investment, and pressures to take collective action on shared problems, adds to the complexity of this task. The paper argues that health is integral to building stable and sustainable societies, and that there are opportunities to develop more holistic approaches that bring together hitherto separate policy spheres.

show abstract

Review Paper: The Challenge of Emerging Zoonoses in Asia Pacific

Cited by 31 publications

References 10 publications

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

Health Policy inAsia and thePacific: Navigating Local Needs and Global Challenges

Health Policy in Asia and the Pacific: Navigating Local Needs and Global Challenges

Contact Info

Product

Resources

About