Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

Chen, Shuo; Sun, Yang; Fan, Xiangyu; Xu, Yazhe; Chen, Shanshan; Zhang, Xinhao; Man, Baoyuan; Yang, Cheng; Du, Jie

doi:10.1186/s12951-023-01898-z

Cited by 13 publications

(6 citation statements)

References 212 publications

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“…The measured resistance and transconductance values indicate that the main response is the shift of the Dirac peak position. The behavior can be explained with a doping change in the graphene channel caused by the change in the gate capacitance. , After the NaCl concentration series, an additional measurement was done in DIW to ensure that the devices return to the baseline established in the DIW characterization (Figure SI2).…”

Section: Resultsmentioning

confidence: 99%

Wafer-Scale Graphene Field-Effect Transistor Biosensor Arrays with Monolithic CMOS Readout

Soikkeli,

Murros,

Rantala

et al. 2023

ACS Appl. Electron. Mater.

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The reliability of analysis is becoming increasingly important as point-of-care diagnostics are transitioning from single-analyte detection toward multiplexed multianalyte detection. Multianalyte detection benefits greatly from complementary metal-oxide semiconductor (CMOS) integrated sensing solutions, offering miniaturized multiplexed sensing arrays with integrated readout electronics and extremely large sensor counts. The development of CMOS back end of line integration compatible graphene field-effect transistor (GFET)-based biosensing has been rapid during the past few years, in terms of both the fabrication scale-up and functionalization toward biorecognition from real sample matrices. The next steps in industrialization relate to improving reliability and require increased statistics. Regarding functionalization toward truly quantitative sensors, on-chip bioassays with improved statistics require sensor arrays with reduced variability in functionalization. Such multiplexed bioassays, whether based on graphene or on other sensitive nanomaterials, are among the most promising technologies for label-free electrical biosensing. As an important step toward that, we report wafer-scale fabrication of CMOS-integrated GFET arrays with high yield and uniformity, designed especially for biosensing applications. We demonstrate the operation of the sensing platform array with 512 GFETs in simultaneous detection for the sodium chloride concentration series. This platform offers a truly statistical approach on GFET-based biosensing and further to quantitative and multianalyte sensing. The reported techniques can also be applied to other fields relying on functionalized GFETs, such as gas or chemical sensing or infrared imaging.

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Section: Resultsmentioning

confidence: 99%

Wafer-Scale Graphene Field-Effect Transistor Biosensor Arrays with Monolithic CMOS Readout

Soikkeli,

Murros,

Rantala

et al. 2023

ACS Appl. Electron. Mater.

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“… Chemical properties: To enhance the functionality of biosensors, it is important to consider the chemical properties of nanocellulose. Nanocellulose contains hydroxyl groups that can be chemically modified, allowing for the attachment of sensing molecules or nanoparticles [ 87 ]. Optical properties: The optical properties of 2D materials such as graphene and transition metal dichalcogenides improve biomolecule detection in optical biosensors.…”

Section: Advantages Of 2d Materials and Cellulose In Biosensorsmentioning

confidence: 99%

Section: Advantages Of 2d Materials and Cellulose In Biosensorsmentioning

confidence: 99%

Advancement in Biosensor Technologies of 2D MaterialIntegrated with Cellulose—Physical Properties

Ramezani,

Stiharu,

van de Ven

et al. 2023

Micromachines

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This review paper provides an in-depth analysis of recent advancements in integrating two-dimensional (2D) materials with cellulose to enhance biosensing technology. The incorporation of 2D materials such as graphene and transition metal dichalcogenides, along with nanocellulose, improves the sensitivity, stability, and flexibility of biosensors. Practical applications of these advanced biosensors are explored in fields like medical diagnostics and environmental monitoring. This innovative approach is driving research opportunities and expanding the possibilities for diverse applications in this rapidly evolving field.

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“…Li et al [ 22 ] reviewed the recent advances in wearable devices based on flexible field-effect transistors including sensors for pressure, temperature, chemical, and biological analytes. Chen et al [ 23 ] provided critical evaluation on multidisciplinary technical details, including sensing mechanism in detecting biomolecules, response signal type, sensing performance optimization, and the integration strategy. Dai et al [ 24 ] review the recent advances of field-effect transistor sensors based on 2D materials, from the material, operating principles, fabrication technologies, proof-of-concept applications, and prototypes, to the challenges and opportunities for their commercialization.…”

Section: Introductionmentioning

confidence: 99%

Field effect transistor based wearable biosensors for healthcare monitoring

Nguyen,

Huynh

et al. 2023

J Nanobiotechnol

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The rapid advancement of wearable biosensors has revolutionized healthcare monitoring by screening in a non-invasive and continuous manner. Among various sensing techniques, field-effect transistor (FET)-based wearable biosensors attract increasing attention due to their advantages such as label-free detection, fast response, easy operation, and capability of integration. This review explores the innovative developments and applications of FET-based wearable biosensors for healthcare monitoring. Beginning with an introduction to the significance of wearable biosensors, the paper gives an overview of structural and operational principles of FETs, providing insights into their diverse classifications. Next, the paper discusses the fabrication methods, semiconductor surface modification techniques and gate surface functionalization strategies. This background lays the foundation for exploring specific FET-based biosensor designs, including enzyme, antibody and nanobody, aptamer, as well as ion-sensitive membrane sensors. Subsequently, the paper investigates the incorporation of FET-based biosensors in monitoring biomarkers present in physiological fluids such as sweat, tears, saliva, and skin interstitial fluid (ISF). Finally, we address challenges, technical issues, and opportunities related to FET-based biosensor applications. This comprehensive review underscores the transformative potential of FET-based wearable biosensors in healthcare monitoring. By offering a multidimensional perspective on device design, fabrication, functionalization and applications, this paper aims to serve as a valuable resource for researchers in the field of biosensing technology and personalized healthcare.

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Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

Cited by 13 publications

References 212 publications

Wafer-Scale Graphene Field-Effect Transistor Biosensor Arrays with Monolithic CMOS Readout

Wafer-Scale Graphene Field-Effect Transistor Biosensor Arrays with Monolithic CMOS Readout

Advancement in Biosensor Technologies of 2D MaterialIntegrated with Cellulose—Physical Properties

Field effect transistor based wearable biosensors for healthcare monitoring

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