Review on the systems biology research of Yin‐deficiency‐heat syndrome in traditional Chinese medicine

Li, Jicheng

doi:10.1002/ar.24354

Cited by 18 publications

(16 citation statements)

References 32 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The group of TCM thematic papers provides results of integrative approaches that reveal new insights about the biology of selected TCM syndromes, their markers, and potential treatments. Three papers cover the topic of Yin ‐deficiency‐heat syndrome, the first of which reviews the biology of this TCM syndrome (Jiang & Li, 2020). The second and third papers focus on potential biomarkers for the same TCM syndrome (Chen et al, 2020; Yi et al, 2020).…”

Section: Figurementioning

confidence: 99%

The Anatomical Record continues to replace wonder with knowledge through first‐hand experience of acupuncture

Albertine

Laitman

2020

The Anatomical Record

View full text Add to dashboard Cite

A group of original papers is assembled for this thematic‐papers issue on traditional Chinese medicine (TCM). The idea for a thematic‐papers issue came from Associate Editor and Guest Editor, Jicheng Li. Jicheng's idea was to introduce concepts and studies of TCM to the editorial board of The Anatomical Record and the Journal's readership. Thus, nine papers are published that deal with biomarkers, animal models, or treatments of TCM syndromes. Uniquely, Jicheng's effort culminated in acupuncture treatment of the editorial board members by a licensed physician of TCM. We learned, first‐hand by Dr. Weixue Wang, about this ancient and vibrant holistic philosophy and medical practice. Our pleasure is to share the topic and our experience with you.

show abstract

Section: Figurementioning

confidence: 99%

The Anatomical Record continues to replace wonder with knowledge through first‐hand experience of acupuncture

Albertine

Laitman

2020

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Systems biology methodologies, such as genomics, proteomics, and metabolomics, have showed significant advantages in studying the specific symptoms in TCM and the herbal formula’s comprehensive mechanism of action ( Cai et al, 2018 ; Jiang and Li, 2020 ). And therefore, proteomics and metabolomics have been applied to explore SMI’s molecular mechanism.…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Serum Proteomic Analysis Helps to Explore the Comprehensive Mechanism and Identify Serum Biomarkers of Shengmai Injection’s Effect on Isoproterenol-Induced Myocardial Ischemia in Rats

Zhang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Shengmai injection (SMI), a traditional Chinese medicine formula with the nature of multicomponent and multi-target, has been widely used in clinic for treating cardiovascular diseases in China; however, its comprehensive mechanism of action remains unclear. In this study, a TMT-based quantitative serum proteomics was performed to explore SMI’s global mechanism and help identify serum biomarkers of its effect on isoproterenol (ISO)-induced myocardial ischemia rats. The results of TMT-based proteomic analysis identified 227, 100, and 228 differentially expressed proteins (DEPs) for the model compared to the control group, SMI pretreatment + model compared to the model group, and SMI pretreatment + model compared to the control group, respectively. Based on bioinformatics analyses of gene ontology (GO), KEGG pathways, and the protein-protein interaction (PPI) networks for the DEPs, it is concluded that the comprehensive mechanism of SMI’s effect on ISO-induced myocardial ischemia injury includes regulation of energy metabolism, reducing endothelial cell permeability, regulation of vessel and cardiac contractility, anti-inflammation, and prevention of cell apoptosis. Furthermore, 10 common DEPs were found, and six of them were regulated in model vs. control group, while back-regulated in SMI pretreatment + model vs. model group. Among them, three functional proteins of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Fas apoptotic inhibitory molecule 3 (FAIM3), and uncharacterized protein (M0R5J4), which were verified by the PRM analysis, might be the potential serum biomarkers on SMI’s effects. Overall, this serum proteomics of SMI not only provides insights into the comprehensive mechanism underlying SMI’s effects on ischemic heart disease but also helps identify serum biomarkers for directing SMI’s cardioprotective effects.

show abstract

“…Transcriptomics is a technique used to study gene transcription and regulation related to TCM syndromes and is conducive to in-depth biological research toward a better understanding of the pathogenesis of TCM syndromes, and so warrants more prevalent application in TCM syndrome research ( Jiang and Li, 2020 ). Gan et al (2020) studied Yin deficiency–heat syndrome using transcriptomics technology and obtained its potential biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Study on the Effect of Macrophages on Vascular Endothelium in Mice With Different TCM Syndromes of Dyslipidemia and its Biological Basis Based on RNA-Seq Technology

Chen

Yang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Background: “Treating the same disease with different methods” is a Traditional Chinese medicine (TCM) therapeutic concept suggesting that, while patients may be diagnosed with the same disease, they may also have different syndromes that require distinct drug administrations.Objective: This study aimed to identify the differentially expressed genes and related biological processes in dyslipidemia in relation to phlegm–dampness retention (PDR) syndrome and spleen and kidney Yang deficiency (SKYD) syndrome using transcriptomic analysis.Methods: Ten ApoE−/− mice were used for the establishment of dyslipidemic disease–syndrome models via multifactor-hybrid modeling, with five in the PDR group and five in the SKYD group. Additionally, five C57BL/6J mice were employed as a normal control group. Test model-quality aortic endothelial macrophages in mice were screened using flow cytometry. Transcriptomic analysis was performed for macrophages using RNA-Seq.Results: A quality assessment of the disease–syndrome model showed that levels of lipids significantly increased in the PDR and SKYD groups, compared to the normal control group, p < 0.05. Applying, in addition, hematoxylin and eosin staining of aorta, the disease model was also successfully established. A quality assessment of the syndrome models showed that mice in the PDR group presented with typical manifestations of PDR syndrome, and mice in the SKYD group had related manifestations of SKYD syndrome, indicating that the syndrome models were successfully constructed as well. After comparing the differentially expressed gene expressions in macrophages of the dyslipidemic mice with different syndromes, 4,142 genes were identified with statistical significance, p < 0.05. Gene ontology analysis for the differentially expressed genes showed that the biological process of difference between the PDR group and the SKYD group included both adverse and protective processes.Conclusion: The differentially expressed genes between PDR syndrome and SKYD syndrome indicate different biological mechanisms between the onsets of the two syndromes. They have distinctive biological processes, including adverse and protective processes that correspond to the invasion of pathogenic factors into the body and the fight of healthy Qi against pathogenic factors, respectively, according to TCM theory. Our results provide biological evidence for the TCM principle of “treating the same disease with different treatments.”

show abstract

Review on the systems biology research of Yin‐deficiency‐heat syndrome in traditional Chinese medicine

Cited by 18 publications

References 32 publications

The Anatomical Record continues to replace wonder with knowledge through first‐hand experience of acupuncture

The Anatomical Record continues to replace wonder with knowledge through first‐hand experience of acupuncture

A Quantitative Serum Proteomic Analysis Helps to Explore the Comprehensive Mechanism and Identify Serum Biomarkers of Shengmai Injection’s Effect on Isoproterenol-Induced Myocardial Ischemia in Rats

Study on the Effect of Macrophages on Vascular Endothelium in Mice With Different TCM Syndromes of Dyslipidemia and its Biological Basis Based on RNA-Seq Technology

Contact Info

Product

Resources

About