Review on the systemic delivery of insulin via the ocular route

Lee, Yung Chi; Simamora, Pahala; Pinsuwan, Sirirat; Yalkowsky, Samuel H.

doi:10.1016/s0378-5173(01)00920-6

Cited by 35 publications

(14 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, the noninvasive methods for insulin mostly include transdermal [3], nasal [4], pulmonary [5], buccal [6], ocular [7], and rectal [8] routes. However, the delivery of insulin is limited by its short half-life, low permeation rates, and digestion by various proteolytic enzymes [9].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of chitosan–polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin

Zhang

Zhao

et al. 2012

International Journal of Biological Macromolecules

155

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of chitosan–polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin

Zhang

Zhao

et al. 2012

International Journal of Biological Macromolecules

155

View full text Add to dashboard Cite

“…Proper use of glucose sensors that will drive a mechanical system involves technical difficulties that need to be overcome. Certainly, there is adequate incentive to continue broad-based efforts into novel approaches to insulin delivery so that the quality of life of diabetic patients can be improved [Lee et al, 2002;Cefalu et al, 2002;Heinemann et al, 2001]. The researched insulin delivery systems reported here are recently discovered, and they are thought to offer a potential to improve compliance and therefore help reduce the number of complications arising from diabetes.…”

Section: Resultsmentioning

confidence: 97%

Recent strategies and methods for improving insulin delivery

Lin

Gokhale

Trivedi³

et al. 2004

Drug Development Research

View full text Add to dashboard Cite

Subcutaneous insulin has been used to treat diabetes since the discovery of insulin itself. However, despite a number of different formulations and routes of administration, intensive insulin therapy without limitations, such as too low bioavailability, has not enjoyed widespread clinical acceptance. Attempts to find effective, well-tolerated routes for delivering insulin began in the late 1920s and as of today, an ideal insulin delivery is still formidable. The most recent advances in insulin delivery are focused on using the inhalation route. The recent European filing of inhaled insulin (Exubera) is providing hope for alternative delivery routes, for example. This article reviews recent advances and approaches that hold promise toward the successful development of insulin delivery for the management of diabetes. Drug Dev.

show abstract

“…In general, the main routes of drug penetration in the intestinal membrane are defined as the transcellular and paracellular routes (Tanaka et al, 1995). Insulin is known to pass through cells by paracellular and transcellular transport (Lee et al, 2002), and NaTC was shown to increase paracellular absorption by opening tight junctions between epithelial cells (Johansson et al, 2002). Therefore, it was thought that the use NaTC in liposomes might increase the penetration of insulin.…”

Section: Discussionmentioning

confidence: 99%