Review on the Significance of Quinazolinone Derivatives as Potent Antihyperglycemic Agents

Abstract

Diabetes mellitus is a chronic metabolic disease which is characterized by high blood sugar levels over a prolonged period of time. Uncontrolled hyperglycemia can lead to serious damage to many vital organs in the body, including kidney damage, heart disease, and nerve damage. The goal of treatment of diabetes mellitus is reduction of blood glucose levels and controlling subsequent complications. Different mechanisms are involved in diabetes mellitus treatment.Quinazolinone and its derivatives have been found as effective and versatile pharmacophoric units in medicinal chemistry to design and develop a wide range of bioactive compounds.The present review summarizes the advances in lead compounds of quinazolinone hybrids and their related heterocycles in treatment of diabetes mellitus. Moreover, the review also helps to intensify the drug development process by providing an understanding of the potential role of these hybridized pharmacophoric features in exhibiting the hypoglycemic effect.

Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents

“…Presently, several classifications of drugs have been already on the market for treating type-1 and type-2 diabetes having standard pharmacological actions including sulphonylurea (insulin secretagogues) [14], glinides (repaglinide, nateglinide) [15], biguanides (metformin) [16], glitazones (rosiglitazone, pioglitazone) [17], α-glucosidase inhibitors (miglitol, acarbose) [18,19] and thiazolidinediones (insulin sensitizers) [8,20]. Quinazolinone & its analogs have supported themselves as an effective compound in medicinal chemistry in developing & designing bioactive compounds [21]. The nitrile group is used more often as an effective pharmacophore in planning the number of DPP-4 inhibitor drugs [22,23].…”

Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides

“…Another popular N-heterocycle for the design of the new aglucosidase inhibitors is quinazolinone ring. 14,15 Several series of the quinazolinone derivatives with high inhibitory activity against a-glucosidase have been reported. For example, simple quinazolinone derivative B was around 30 times more potent than acarbose (Fig.…”