Review on the pharmacological and health aspects of Hylocereus or Pitaya: An update

Safira, Arifia; Savitri, Sonya Lerky; Putri, Aliyyah Revinda Bima; Hamonangan, Jonathan Mark; Safinda, Bella; Solikhah, Tridiganita Intan; Khairullah, Aswin Rafif; Puspitarani, Gavrila Amadea

doi:10.22270/jddt.v11i6.5181

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…These properties are derived from the multi-bioactive compounds found in this plant, mainly in the fruit. Furthermore, it shows no toxicity since a study with dragon fruit extract at a dose of 1250 to 5000 mg/kg did not produce interferences or abnormalities in the organs of animal models [ 65 , 66 , 67 , 68 ]. Below it is possible to find some effects of pitaya fruit.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds

et al. 2023

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Dragon fruit (Hylocereus genus) has the potential for the prevention of diseases associated with inflammatory and oxidative processes. We aimed to comprehensively review dragon fruit health effects, economic importance, and possible use in delivery systems. Pubmed, Embase, and Google Scholar were searched, and PRISMA (Preferred Reporting Items for a Systematic Review and Meta-Analysis) guidelines were followed. Studies have shown that pitaya can exert several benefits in conditions such as diabetes, dyslipidemia, metabolic syndrome, cardiovascular diseases, and cancer due to the presence of bioactive compounds that may include vitamins, potassium, betacyanin, p-coumaric acid, vanillic acid, and gallic acid. Moreover, pitaya has the potential to be used in food and nutraceutical products as functional ingredients, natural colorants, ecologically correct and active packaging, edible films, preparation of photoprotective products, and additives. Besides the importance of dragon fruit as a source of bioactive compounds, the bioavailability is low. The development of delivery systems such as gold nanoparticles with these compounds can be an alternative to reach target tissues.

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Section: Discussionmentioning

confidence: 99%

“…The oil results from the seeds, and the peel is also an essential source of antioxidant compounds. The peel of H. undatus possesses more flavonoids than the flesh [ 65 , 66 , 67 , 69 ] ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds

et al. 2023

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“…Pitaya, called dragon fruit, is a cactus with epiphytic and terrestrial traits. This dragon fruit plant requires support poles or other trees (11). The part of dragon fruit that can be utilized as antidiabetic medicine is the peel (reference).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic of Hylocereus polyrhizus peel ethanolic extract on alloxan induced diabetic mice

Solikhah

Rani

Septiani

et al. 2022

IJVS

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Diabetes is a disease characterized by high blood glucose due to the abnormal response of the cells in the body on produced insulin or insulin resistance. Indeed, the treatment for diabetes mellitus lasts for a lifetime and causes various side effects, such as headache, hypoglycemia, vomiting, and gastrointestinal symptoms. Interestingly, Dragon fruit has potent antidiabetic activity and without side effects. Thirty Wistar mice were included in the study. Alloxan with a dose of 150 mg/kg was injected intraperitoneally to all groups except the standard control group. Mice with blood glucose levels higher than 200 mg/dL were considered diabetic and employed throughout the study. Mice were divided into five groups: standard control group without alloxan, diabetic control group with alloxan, treatment group of 100 mg/kg and 300mg/kg H. polyrhizus peel extract, and positive control group with 600 µg/kg glibenclamide. All treatments were given orally. Blood glucose level was checked on day 1, 7, and 14 on all groups using Accu-check instant glucometer. This study revealed that administration of alloxan to the diabetic control group significantly increased blood glucose level compared to the normal control group on day-1, 7, and 14 (P < 0.05). In addition, administration of H. polyrhizus peel extract and glibenclamide effectively decreases blood glucose levels, especially on day-7 and 14 compared to the control group (P<0.05).

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“…It belongs to the parsley family and usually acts as an effective remedy against numerous inflammatory diseases such as bronchitis, bronchial asthma, arthritis, and hepatitis [16][17][18]. At the same time, celery has a substantial role in inhibiting appetite, reducing body weight, and preventing hypertension through its diuretic, antioxidant, and anti-inflammatory properties [12,19].…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits

Mousa

Allemailem

Alhumaydhi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Patients treated with cyclophosphamide (CP) usually suffer from severe hemorrhagic cystitis (HC). Our previous study exhibited that mesna + celery cotherapy partially ameliorated HC. Therefore, there is a substantial need to seek alternative regimens to get complete protection against CP-induced HC. The current study investigated the effects of mesna + celery seed oil (MCSO) or mesna + manuka honey (MMH) cotherapy against CP-induced HC in adult male rabbits. The forty rabbits were divided into four equal groups and treated for three weeks. The control group (G1) received distilled water and the second group (G2) received CP (50 mg/kg/week). The third group (G3) received CP + MCSO (CPMCSO regimen), and the fourth group (G4) received CP + MMH (CPMMH regimen). The urinary bladder (UB) specimens were processed to evaluate UB changes through histopathological, immunohistochemical, ultrastructural, and biochemical investigations. In G2, CP provoked HC features (urothelial necrosis, ulceration, and sloughing), UB fibrosis, and TNF-α immunoexpression. Besides, CP reduced the activity of antioxidant enzymes (GPx1, SOD3, and CAT) and elevated the serum levels of NF-κB, TNF-α, IL-1B, and IL-6 cytokines in G2 rabbits. In contrast, the CPMMH regimen caused significant increments of UB protection against HC in G4 rabbits compared to the partial protection by the CPMCSO regimen in G3. Therefore, our study indicated for the first time that the novel CPMMH regimen resulted in complete UB protection against CP-induced HC via combined antioxidant, anti-inflammatory, and antifibrotic properties.

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Review on the pharmacological and health aspects of Hylocereus or Pitaya: An update

Cited by 12 publications

References 31 publications

Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds

Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds

Antidiabetic of Hylocereus polyrhizus peel ethanolic extract on alloxan induced diabetic mice

Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits

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