Review on the genus Brugmansia: Traditional usage, phytochemistry, pharmacology, and toxicity

Algradi, Adnan Mohammed; Liu, Yan; Yang, Bing‐You; Kuang, Hai‐Xue

doi:10.1016/j.jep.2021.113910

Cited by 6 publications

(6 citation statements)

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“…The use of herbal/natural drugs as complementary/alternative medicines is gaining popularity throughout the world and many drugs are directly extracted from plants, whereas others are chemically modified [14]. Phytochemical exploration of the ethanolic extract of the Taif's rose stem and leaves revealed the presence of cardiac glycosides, alkaloids, and phenolic compounds.…”

Section: Discussionmentioning

confidence: 99%

“…Thousands of plant species are employed in many traditional systems of medicine around the world and are recognized for their contributions to contemporary medicine, with some of them, such as Brugmansia and Rosa species, being used to treat cancer and cardiovascular problems [13,14]. The use of medicinal plants is a centuries-old tradition, and recent advances in contemporary therapies have boosted the use of natural products for a variety of maladies and disorders around the world [15].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Galal

Al-Yasi

Fawzy

et al. 2022

Life

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This study investigated the phytochemical contents of Taif’s rose pruning wastes and their potential application as phytomedicine, thereby practicing a waste-recycling perspective. In the Al-Shafa highland, four Taif rose farms of various ages were chosen for gathering the pruning wastes (leaves and stems) for phytochemical and pharmacological studies. The leaves and stems included significant amounts of carbohydrates, cardiac glycosides, alkaloids, flavonoids, and other phenolic compounds. The cardiac glycoside and flavonoid contents were higher in Taif rose stems, while the phenolic and alkaloid contents were higher in the plant leaves. Cardiovascular glycosides (2.98–5.69 mg g−1), phenolics (3.14–12.41 mg GAE g−1), flavonoids (5.09–9.33 mg RUE g −1), and alkaloids (3.22–10.96 mg AE g−1) were among the phytoconstituents found in rose tissues. According to the HPLC analysis of the phenolic compounds, Taif’s rose contains flavonoid components such as luteolin, apigenin, quercetin, rutin, kaempferol, and chrysoeriol; phenolics such as ellagic acid, catechol, resorcinol, gallic acid, and phloroglucinol; alkaloids such as berbamine, jatrorrhizine, palmatine, reticuline, isocorydine, and boldine. Warm water extract was highly effective against Bacillus subtilis, Escherichia coli, and Proteus vulgaris, whereas methanol and cold water extracts were moderately effective against Aspergillus fumigatus and Candida albicans. The study’s findings suggested that Taif’s rose wastes could be used for varied medical purposes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Galal

Al-Yasi

Fawzy

et al. 2022

Life

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“…Alkaloids are physiologically-active substances that are frequently employed as medications and produced by plants as secondary metabolites, but many of these substances are extremely toxic [60]. Six alkaloid compounds were isolated and identified in TR extracts as berbamine, jatrorrhizine, palmatine, reticuline, isocorydine, and boldine (Table A1 and Figure 3).…”

Section: Hplc Of Phytochemical Compoundsmentioning

confidence: 99%

“…Five phenolic substances were produced by the HPLC of the extracts of the different TR organs: ellagic acid, catechol, resorcinol, gallic acid, and phloroglucinol (Annex 1 and Figure 2). The five compounds were found in plant stems and leaves, while resorcinol and Alkaloids are physiologically-active substances that are frequently employed as medications and produced by plants as secondary metabolites, but many of these substances are extremely toxic [60]. Six alkaloid compounds were isolated and identified in are choleretic substances [62].…”

Section: Hplc Of Phytochemical Compoundsmentioning

confidence: 99%

Chemical and Nutritional Characterization of the Different Organs of Taif’s Rose (Rosa damascena Mill. var. trigintipetala) and Possible Recycling of the Solid Distillation Wastes in Taif City, Saudi Arabia

et al. 2022

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The objective of the current study was to examine the chemical composition and biological functions of the various Taif’s rose (TR) organs and floral solid distillation wastes (SDW). Additionally, it assessed the SDW’s potential use in animal feed and potential health applications. For chemical and biological analyses, the plant stems, leaves, and flowers as well as the SDW of TR were gathered from four farms in the Al-Shafa highland region of Taif, Saudi Arabia. The highest levels of cardiac glycosides, flavonoids, and phenolics were found in the flowers (7.66 mg securiaside g−1, 16.33 mg GAE g−1, and 10.90 mg RUE g−1, respectively), while the highest carbohydrate and alkaloid contents were found in the TR leaves (2.09% and 9.43 mg AE g−1, respectively) with no significant differences from the SDW. Quercetin, apigenin, and rutin flavonoids, as well as isocorydine and boldine alkaloids, were found in larger concentrations in the flowers and floral SDW than in the leaves and stems. The various TR flower extracts were effective against Gram-negative and -positive bacteria but had no effect on fungal strains, but the SDW’s methanol extract was only effective against fungi. The plant stem had the highest N, K, and Mg contents (138, 174, and 96.12 mg kg−1, respectively), while the leaves had the highest P and Ca values (6.58 and 173.93 mg kg−1, respectively). The leaves had the highest contents of total carbohydrates and acid detergent fibre (59.85 and 3.93%, respectively), while the stems had the highest total protein and acid detergent fibre (8.66 and 24.17%, respectively), and the SDW had the highest fats and crude fiber (0.57 and 36.52%, respectively). The highest amounts of digestible crude protein, gross energy, and total dissolved nutrients (TDN) (4.52% and 412.61 Mcal kg−1) were found in the plant stem and flowers, respectively. The results of the current experiment showed that the TDN contents of the various organs and the SDW of TR are suitable for mature dry gestating beef cows. It was determined that, in addition to the SDW’s potential usage as an ingredient in animal feed, various plant parts and TR’s SDW can be utilized for a variety of medical reasons.

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“…Según Caballero-Serrano et al (2019), B. arborea es ampliamente conocida en la medicina tradicional como una planta mágica, sin embargo agregan usos para tratar distintos dolores. Con base en estudios fitoquímicos (Mattioli et al, 2012;Kim et al, 2020;Algradi et al, 2021) realizados a la especie (Brugmansia arborea) se han encontrado alcaloides tales como: la atropina, hioscina, noratropina (Arteaga de García et al, 1993), hiosciamina y escopolamina (Mattioli et al, 2012), de los que en algunos casos ya se les atribuye una actividad analgésica y antiinflamatoria (Addams & Wang, 2015). Del mismo modo, Kim et al, (2020) determinaron la presencia de flavonoides como kaempferin, kaempferitrin, kaempferol, quercetin, y (+)-aromadendrin; varios de los cuales ya fueron reportados por su efecto antinociceptivo (De Melo et al, 2009, Toker et al, 2004, Almeida-Junior et al, 2020.…”

Section: Introductionunclassified

Evaluación preliminar in vivo de la actividad analgésica de las flores de Brugmansia arborea “floripondio”

et al. 2023

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Objetivo: investigar el efecto analgésico de la decocción de las flores de Brugmansia arborea “floripondio” en ratones de laboratorio.Metodología: para determinar la actividad analgésica se emplearon 9 ratones albinos (machos) de la cepa NIH de 5 semanas de edad con un peso corporal entre 21 - 24.5 g|, todos procedentes del Laboratorio de Experimentación Animal del Centro de Investigación y Desarrollo en Salud de la Universidad de El Salvador. Para la preparación de la decocción se colocaron 5 g del material vegetal fresco (flores) en 50 ml de agua hasta su ebullición. Luego se administró por vía oral la decocción de las flores de Brugmansia arborea a una concentración de 0.1g/mL. Los ratones fueron divididos en tres grupos, un grupo control negativo (agua destilada), un grupo control positivo (Ibuprofeno 200 mg/kg) y el grupo tratamiento (decocción de las flores de floripondio). Una hora después de administradas las sustancias se inyectó ácido acético al 1 % por vía intraperitoneal. Después de cinco minutos, se contó el número de contorsiones abdominales a cada animal. Resultados: los grupos administrados con Ibuprofeno y el tratamiento obtuvieron una media de 11.33 y 15.67 respectivamente, disminuyendo considerablemente el número de contorsiones abdominales en comparación al grupo tratado con agua destilada, el cual obtuvo una media de 34.67. Conclusiones: la decocción de las flores de Brugmansia arborea en la prueba de ácido acético mostró que tiene un potencial efecto analgésico en ratones de laboratorio.

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Review on the genus Brugmansia: Traditional usage, phytochemistry, pharmacology, and toxicity

Cited by 6 publications

References 128 publications

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Evaluation of the Phytochemical and Pharmacological Potential of Taif’s Rose (Rosa damascena Mill var. trigintipetala) for Possible Recycling of Pruning Wastes

Chemical and Nutritional Characterization of the Different Organs of Taif’s Rose (Rosa damascena Mill. var. trigintipetala) and Possible Recycling of the Solid Distillation Wastes in Taif City, Saudi Arabia

Evaluación preliminar in vivo de la actividad analgésica de las flores de Brugmansia arborea “floripondio”

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