Review on the ethnomedicinal, phytochemical and pharmacological properties of Piper sarmentosum: scientific justification of its traditional use

Seyyedan, Atefeh; Yahya, Farhana; Kamarolzaman, Mohammad Fauzi Fahmi; Suhaili, Zarizal; Desa, Mohd Nasir Mohd; Khairi, Hussain Mohd; Somchit, M. N.; ., C.A. Fatimah; Teh, Lay Kek; Salleh, Mohd Zaki; Zakaria, Zainul Amiruddin

doi:10.5667/tang.2013.0002

Cited by 5 publications

(4 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are numerous studies from the Southeast Asian region that indicate the beneficial values of P. sarmentosum (i.e. fruit, leave, stem) to cure various illnesses (Seyyedan et al 2013). In Malaysia, P. sarmentosum has long been used to treat diabetes mellitus, mouth-related problems such as gum infection and curing other ailments as well as reducing white discharge during the menstrual cycle (Subramaniam et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Qualitative Phytochemical Analysis and Antimicrobial Activity of Piper sarmentosum Leaves Extract Against Selected Pathogens

Yusof

Radzi

Richard

2019

JSKM

View full text Add to dashboard Cite

The controversial usage of antiseptic in treating wound infections had become a huge issue over the years due to its minimal effectiveness and high toxicity level that are harmful to humans. Hence, numerous studies had been carried out to determine other possible approaches including herbal remedies. The alarming situation had led us to study on Piper sarmentosum and its antimicrobial activity against selected pathogens. In present study, methanol extract of Piper sarmentosum leaves were prepared to investigate the presence of phytochemical compounds. The in vitro antimicrobial activity of crude methanolic extract was evaluated using disc diffusion and microdilution broth methods. The study demonstrated the antimicrobial activity of leaves extract against Staphylococcus aureus (7 mm) and Escherichia coli (6.5 mm). However, no zone of inhibition was observed against Pseudomonas aeruginosa. Meanwhile, the MIC values for Staphylococcus aureus was 6.25 mg/mL whilst Escherichia coli was 12.5 mg/mL. In addition, the phytochemical screening results revealed that the extract contained glycosides, flavonoids, terpenoids, alkaloids and phenolics. In conclusion, methanolic extract of Piper sarmentosum leaves has the potential as a new, effective alternative towards current drugs that are available for skin-associated infection. The findings from this study are crucial in providing latest information of the plant's additional values that can be incorporated as a baseline for current and future studies as well as in investigating other possible plants that are beneficial for health purposes, particularly for combating skin-associated infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Qualitative Phytochemical Analysis and Antimicrobial Activity of Piper sarmentosum Leaves Extract Against Selected Pathogens

Yusof

Radzi

Richard

2019

JSKM

View full text Add to dashboard Cite

show abstract

“…The plant is widely used in Southeast Asia as a potent antidiabetic medication (7). Extensive research has been undertaken over the years to examine the biological effects of P. sarmentosum and its potential for treating oxidative stress-related disorders such as hypertension and diabetes, which has offered more support for its traditional usage (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Piper Sarmentosum: A Systematic Review

Azhar¹,

Ibrahim²,

Muniandy³

2022

MJMHS

View full text Add to dashboard Cite

Introduction: Diabetes mellitus (DM) is an endocrine, metabolic syndrome and has reached pandemic proportions worldwide. The multifactorial pathology results in the patient to including lifelong drug therapy for treatment. Alternative medicines such as traditional remedies using plant herbs to treat various diseases are common in most countries. Piper sarmentosum extracts have been as a traditional medicine to treat various diseases. The plant has abundant phytochemical properties such as alkaloids and flavonoids exhibiting pharmacological activities such as antidiabetic effects, antioxidant, anti-inflammatory, and anticancer. This paper aims to appraise the data into a comprehensive systematic review on the antidiabetic effect of P. sarmentosum and it’s potential in managing DM. Methods: This systematic review used the PRISMA method with searches in three electronic databases such as SCOPUS, PUBMED and WEB OF SCIENCE in November 2021. Six articles were included based on the inclusion criteria. Results: The results showed a hypoglycaemic effect in induced diabetic models. Piper sarmentosum extracts significantly reduces fasting blood glucose and reduces the risk of diabetes complications related to renal and cardiovascular system. In summary, a promising result regarding antidiabetic activity was found. Conclusion: This finding suggests that this plant has the potential to be used as an alternative therapy or pair along with other medications to treat DM.

show abstract

“…is an herbaceous plant that is commonly found in Southeast Asia. Traditionally, P. sarmentosum leaves have been used to treat cough, flu, and rheumatism (Seyyedan et al 2013). Pharmacologically, the aqueous extract of P. sarmentosum leaves has antihypertensive (Zainudin et al 2015), antioxidant (Hussain et al 2009), and antihypercholesterolemic actions (Amran et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Quantified Piper sarmentosum Roxb. Leaves Aqueous Leaf Extract and Its Antihypertensive Effect in Dexamethasone-Induced Hypertensive Rats

Azmi¹,

Aminuddin²,

Jamal³

et al. 2021

JSM

View full text Add to dashboard Cite

The quality control of raw herbal materials is important to ensure the safety, efficacy, and reproducibility of herbal products. Herbal products with consistent efficacy should be standardized and quantified based on their bioactive phytochemical compounds. Piper sarmentosum Roxb. has been reported for its antihypertensive activity. However, its antihypertensive effect on dexamethasone-induced hypertension still lacks information. In this study, the quality of two batches of raw P. sarmentosum leaf materials was assessed for heavy metal and microbial contents, and their aqueous extracts were assayed for antioxidant activity. The aqueous extract of the second batch of P. sarmentosum leaves was the only extract that passed the heavy metal and microbial limits and had the highest antioxidant activity (50.00 ± 2.88%); therefore, this extract was used for subsequent studies. The extract was quantified for two phytochemical markers, rutin (0.09 ± 0.002%) and vitexin (0.23 ± 0.007%), using a validated ultrahigh performance liquid chromatography method. The quantified extract (500 mg/kg/day orally) was able to lower the systolic blood pressure, diastolic blood pressure, and mean arterial pressure of dexamethasone-induced hypertensive rats comparable to the positive control drug, captopril. In summary, the quantified aqueous extract of P. sarmentosum based on rutin and vitexin lowers the blood pressure of dexamethasone-induced hypertensive rats, but its underlying mechanism warrants further investigation.

show abstract

Review on the ethnomedicinal, phytochemical and pharmacological properties of Piper sarmentosum: scientific justification of its traditional use

Cited by 5 publications

References 51 publications

Qualitative Phytochemical Analysis and Antimicrobial Activity of Piper sarmentosum Leaves Extract Against Selected Pathogens

Qualitative Phytochemical Analysis and Antimicrobial Activity of Piper sarmentosum Leaves Extract Against Selected Pathogens

Antidiabetic Effect of Piper Sarmentosum: A Systematic Review

Quantified Piper sarmentosum Roxb. Leaves Aqueous Leaf Extract and Its Antihypertensive Effect in Dexamethasone-Induced Hypertensive Rats

Contact Info

Product

Resources

About