Review on pharmacological activities of liriodenine

Chen, Chung‐Yi

doi:10.5897/ajpp2013.3477

Cited by 18 publications

(17 citation statements)

References 39 publications

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“…Alkaloids can interfere with tubulin polymerization or stabilize the DNA topoisomerase complex [23]. The biological activity of liriodenine can be attributed to the intercalation between neighboring base pairs of the DNA double helix [24,25].…”

Section: Discussionmentioning

confidence: 99%

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Antileishmanial activity of Annona species (Annonaceae)

et al. 2020

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Annona species are widely used in traditional medicine against leishmaniasis. In vitro studies have confirmed their antileishmanial activity. Objective: review the antileishmanial activity of Annona species. Results: This article provides a review Annona species activity against leishmaniasis, in which it suggests that extracts of A. mucosa were active against promastigotes and amastigotes of L. amazonensis. Moreover, extracts of A. crassiflora were active only against promastigotes of L. donovani, whereas the extract, alkaloid fraction and liriodenine of A. foetida were active against promastigotes of L. braziliensis and L. guyanensis. Liriodenine was also very active against L. amazonensis. Furthermore, extracts and fractions from stems of A. muricata were active against Leishmania sp. This activity may be related to the presence of acetogenins, since fractionation contributed to increase activity. The fractionation of A. purpurea extract contributed to antileishmanial activity, and resulted in a fraction with high selectivity. Such activity may be related to alkaloids or acetogenins. Conclusions: In this review article it is suggested that Annona species are promising as leishmanicide and this activity may be related to acetogenins and alkaloids.

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Section: Discussionmentioning

confidence: 99%

“…The oxo function induces cytotoxicity on precursor incorporation into DNA [25,26]. Indeed, acetogenins binds to complex I of the mitochondrial electron transport chain [27,28].…”

Section: Discussionmentioning

confidence: 99%

Antileishmanial activity of Annona species (Annonaceae)

et al. 2020

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“…In contrast, the presence of oxaporphine alkaloids on leaf dichloromethane extract, mainly liriodenine, may partially justify the results for DE samples 3,14 . Although the mechanism of alkaloid action in Leishmania species is not yet understood, DNA topoisomerase inhibitors have been reported as promising antileishmanial drugs 15 , highlighting that liriodenine belongs to this group of substances 14 .…”

Section: /5mentioning

confidence: 91%

In vivo antileishmanial activity of Annona mucosa extracts

Lima

Pinheiro

Allaman

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem. Methods: Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa. Results: Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels. Conclusions: Extracts of A. mucosa are promising sources of novel antileishmanial compounds.

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“…Liriodenine, was identified of having antimicrobial, antibiotic, antifungal, antitumor, cardiovascular effects and antiplatelet properties and actions [14]. In this study, four alkaloids were isolated and identified as liriodenine (1), O-methylmoschatoline (2), lysicamine (3) and cepharadione-A (4) ( Figure 1).…”

Section: Introductionmentioning

confidence: 89%

“…Compound 1 was isolated for the first time from Liriodendron tulipifera L., and followed by other plant species [15]. Most are found in the families of Magnoliaceae, Annonaceae, Rutaceae, Monimiaceae, and Menispermaceae [14]. This compound was obtained as yellow needles.…”

Section: Structural Elucidationmentioning

confidence: 98%

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

Kan¹,

Ahmad²,

Azziz³

et al. 2019

jrp

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Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The structures of the isolated compounds were elucidated based on their spectral data (1 H, 13 C and LCMS) and reports in the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on the genus of Platymitra.

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Review on pharmacological activities of liriodenine

Cited by 18 publications

References 39 publications

Antileishmanial activity of Annona species (Annonaceae)

Antileishmanial activity of Annona species (Annonaceae)

In vivo antileishmanial activity of Annona mucosa extracts

Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line

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