Review on Newly Identified Corona Virus and its Genomics Organization

Abstract

Human Coronaviruses (HCoV) exhibit positive single stranded RNA genome with enveloped nucleocapsid. Coronavirus belongs to the family Coronaviridae, originated from avian and mammalian species causes upper respiratory tract infection in humans by novel HCoVs viruses named as HCoV-HKU1, HCoV-NL63 but predominant species is Middle East respiratory syndrome (MERS-CoV) across the world. HCoV-HKU1 sp. is associated with chronic pulmonary disease, while HCoV-NL63 causes upper and lower respiratory tract disease in both children and adults, but most recent one was MERS-CoV, which caused acute pneumonia and occasional renal failure. The novel coronavirus SARS-CoV-2 is a new strain that causes the Coronavirus Disease 2019 (COVID-19) as named by the World Health Organization. According to the recent world statistics report about the COVID-19 cases approx. 101,500 confirmed cases and 3,500 death cases appeared. And mostly, a case of infection with CoV was identified in Wuhan, China. Structurally viral genome constitutes of 2/3rd of replicase gene encoding ORFs regions and rest of the 1/3rd region of genome form the structural proteins. The aim of the study was to understand the viral genetic systems in order to facilitate the genetic manipulation of the viral genome and to know the fundamental mechanism during the viral replication, facilitating the development of antidotes against the virus.

COVID-19 disruption on college students: Academic and socioemotional implications.

“…With the medical communities working fervently on diagnostic, preventative, and vaccinating abilities (see Rao et al, 2020), social scientists have equally plumbed the breadth and depth of the psychological corollaries of this virus. Researchers are systematically studying various aspects of the virus’ impact, which include (but are not limited to) more public policy−related concepts (Asmundson & Taylor, 2020; Boyle et al, 2020; Garfin et al, 2020); trust in the government (Bao et al, 2020; Berger & Reupert, 2020; Sibley et al, 2020); and investigating the elderly population, the most vulnerable group (Brown et al, 2020; Cudjoe & Abdullah, 2020; Ward et al, 2020).…”

The COVID-19 pandemic: The importance of being alert to zoonoses

“…Los coronavirus (CoVs) son parásitos intracelulares obligados que toman el control de la maquinaria celular del hospedero para hacer copias virales y luego esparcirse (16) . Los CoVs son agentes patógenos que han amenazado a los seres humanos durante miles de años (17) .…”

Nanomedicine & Nanotoxicology Future Could Be Reshaped Post-COVID-19 Pandemic

“…The availability of viral information in record time at the start of the outbreak (Rao et al, 2015;Grifoni et al, 2020; GISAID Next hCoV-9 App, 2020), helped catalyze the design and development of many vaccine candidates. In total, the world health organization (WHO) reported 44 vaccine candidates in clinical trials and 154 in preclinical stages (WHO, 2020b).…”