Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy

Rajan, Arunima; Sahu, Niroj Kumar

doi:10.1007/s11051-020-05045-9

Cited by 93 publications

(48 citation statements)

References 174 publications

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“…Developments in the field of nanotechnology have opened numerous opportunities in the drug development sector in recent decades. Nanoparticles (NPs) having diameters of less than 100 nm (nm) have drawn tremendous attention in medical analysis, delivery of drugs, and therapeutics (Tavakoli and Hashemzadeh 2020 ; Rajan and Sahu 2020 ). As compared to particles fabricated from same substance in higher scales, NPs possess a higher surface to volume ratio, making them more reactive (Argueta-Figueroa et al 2014 ).…”

Section: Copper Based Materials In Fighting Covid-19 Virusmentioning

confidence: 99%

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

et al. 2021

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Copper (Cu) and its alloys are prospective materials in fighting covid-19 virus and several microbial pandemics, due to its excellent antiviral as well as antimicrobial properties. Even though many studies have proved that copper and its alloys exhibit antiviral properties, this research arena requires further research attention. Several studies conducted on copper and its alloys have proven that copper-based alloys possess excellent potential in controlling the spread of infectious diseases. Moreover, recent studies indicate that these alloys can effectively inactivate the covid-19 virus. In view of this, the present article reviews the importance of copper and its alloys in reducing the spread and infection of covid-19, which is a global pandemic. The electronic databases such as ScienceDirect, Web of Science and PubMed were searched for identifying relevant studies in the present review article. The review starts with a brief description on the history of copper usage in medicine followed by the effect of copper content in human body and antiviral mechanisms of copper against covid-19. The subsequent sections describe the distinctive copper based material systems such as alloys, nanomaterials and coating technologies in combating the spread of covid-19. Overall, copper based materials can be propitiously used as part of preventive and therapeutic strategies in the fight against covid-19 virus.

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Section: Copper Based Materials In Fighting Covid-19 Virusmentioning

confidence: 99%

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

et al. 2021

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“…The thermal performance of magnetic NP increases as a function of frequency (f ) and field amplitude (H) [1]. Thus, to compare the obtained results with the ones reported in the literature, performed at different experimental conditions of amplitude and frequency, the corresponding intrinsic loss power (ILP) values are also included on Table 3 and were calculated by ILP = SLP/H 2 f [4,81]. However, this parameter may be applied to compare the outcomes of heating efficiency only when relatively low field strengths (few kA/m) and frequencies (several hundred kHz) are used [4,82], in which the magnetic susceptibility is assumed to be independent of the magnetic field.…”

Section: Hyperthermia Measurementsmentioning

confidence: 99%

“…However, this parameter may be applied to compare the outcomes of heating efficiency only when relatively low field strengths (few kA/m) and frequencies (several hundred kHz) are used [4,82], in which the magnetic susceptibility is assumed to be independent of the magnetic field. Since for clinical magnetic hyperthermia applications it is recommendable to respect the acceptable limits regarding the AMF field and frequency, and NP should be superparamagnetic, this is considered a good approximation [2,81].…”

Section: Hyperthermia Measurementsmentioning

confidence: 99%

Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

et al. 2021

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Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m−1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg−1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.

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“…The minimum temperature difference within the cell (~ 20 μm) to form the polar bleb was found to be 1.3 °C, or over 65 °C mm −1 . Such a large gradient has not been observed in tissues, but it may be formed in thermal therapies using nano-/micromaterial heaters (Rajan and Sahu 2020;Liao et al 2021).…”

Section: Cellular Responses To Spatial Temperature Gradientmentioning

confidence: 99%

Opto-thermal technologies for microscopic analysis of cellular temperature-sensing systems

2021

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Could enzymatic activities and their cooperative functions act as cellular temperature-sensing systems? This review introduces recent opto-thermal technologies for microscopic analyses of various types of cellular temperature-sensing system. Optical microheating technologies have been developed for local and rapid temperature manipulations at the cellular level. Advanced luminescent thermometers visualize the dynamics of cellular local temperature in space and time during microheating. An optical heater and thermometer can be combined into one smart nanomaterial that demonstrates hybrid function. These technologies have revealed a variety of cellular responses to spatial and temporal changes in temperature. Spatial temperature gradients cause asymmetric deformations during mitosis and neurite outgrowth. Rapid changes in temperature causes imbalance of intracellular Ca2+ homeostasis and membrane potential. Among those responses, heat-induced muscle contractions are highlighted. It is also demonstrated that the short-term heating hyperactivates molecular motors to exceed their maximal activities at optimal temperatures. We discuss future prospects for opto-thermal manipulation of cellular functions and contributions to obtain a deeper understanding of the mechanisms of cellular temperature-sensing systems.

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Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy

Cited by 93 publications

References 174 publications

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review

Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

Opto-thermal technologies for microscopic analysis of cellular temperature-sensing systems

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