Review on experiment-based two- and three-dimensional models for wound healing

Abstract

Traumatic and chronic wounds are a considerable medical challenge that affects many populations and their treatment is a monetary and timeconsuming burden in an ageing society to the medical systems. Because wounds are very common and their treatment is so costly, approaches to reveal the responses of a specific wound type to different medical procedures and treatments could accelerate healing and reduce patient suffering. The effects of treatments can be forecast using mathematical modelling that has the predictive power to quantify the effects of induced changes to the wound-healing process. Wound healing involves a diverse and complex combination of biophysical and biomechanical processes. We review a wide variety of contemporary approaches of mathematical modelling of gap closure and wound-healing-related processes, such as angiogenesis. We provide examples of the understanding and insights that may be garnered using those models, and how those relate to experimental evidence. Mathematical modellingbased simulations can provide an important visualization tool that can be used for illustrational purposes for physicians, patients and researchers.

Theoretical perspective on synthetic man‐made life: Learning from the origin of life

“…Further, Stephen Wolfram created the simplest version, called the elementary cellular automata, and comprehensively investigated and classified its various behaviors, also demonstrating their potential application to natural phenomena, published in a notable book “ A New Kind of Science ” [75]. Currently, models of cellular automata not only serve as exemplary demonstrations of emergent behavior but also continue to play a vital role in various areas of research, such as modeling wound healing [76], simulating quantum lattice gases [77], quantum dot cellular automaton [78]. In 1987, Christopher Langton, the scientist mentioned above at the Santa Fe Institute, formally coined the term “artificial life”, ALife for short [79].…”

A note on how to develop interdisciplinary collaborations between experimentalists and theoreticians

“…In many of these papers, experts in theory and experimentation teamed up to work on a problem of significant importance during the programme thereby exemplifying the fruits of interdisciplinary research (articles that form this special issue; [1][2][3][4][5][6][7][8][9][10][11] …”

Wound opening in a thin incompressible viscoelastic tissue

“…Cell and subcellular dynamics, in vivo and in vitro, in response to external stimuli or during the embryonic development of plants and animals, have been the subject of intense research activity during the last decades [1,2]. Among the most popular topics is wound healing, which is a process of tissue regeneration for wound closure.…”