Review on emergence of drug-resistant tuberculosis (MDR &amp; XDR-TB) and its molecular diagnosis in Ethiopia

Saravanan, Muthupandian; Niguse, Selam; Abdulkader, Mahmud; Tsegay, Ephrem; Hailekiros, Haftamu; Gebrekidan, Atsbeha; Araya, Tadele; Pugazhendhi, Arivalagan

doi:10.1016/j.micpath.2018.02.047

Cited by 46 publications

(39 citation statements)

References 29 publications

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“…The most intriguing property of MtbC assured by over 150 virulence factors 5,36 is the capacity of MtbC to survive and multiply in certain conditions inside the macrophages, monocytes and dendritic cells. 8…”

Section: The Emergence Of Drug Resistance Tuberculosismentioning

confidence: 99%

“…6,7 Moreover, in some endemic areas, TB was the first cause of hospital death. 8 Tuberculosis (TB) is a zoonotic and anthropozoonotic disease with a complex pathogenesis, produced by bacteria from Mycobacterium tuberculosis complex (MtbC), mainly M. tuberculosis, and in a lesser amount by the infections with other mycobacteria such as M. bovis, M. africanum, M. caprae, M. canetti, and occasionally Mycobacterium pinnipedii or M. microti. [9][10][11] For some newly included members of MtbC as M. mungi, 12 the exact role in human tuberculosis is currently poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…The emergence of drug-resistant strains of MtbC observed in the last decades gives rise to additional challenges to the anti-TB prevention and control efforts. 8 Nanotechnology and nanoparticle science are emerging disciplines connecting interdisciplinary areas of research such as chemistry, physics, and medicine providing innovative approaches and new-practical solutions for several critical-issues, including bacterial-induced infectious diseases. 13,14 Metallic silver has a long history in medical applications, but its popularity markedly declined following the introduction and broad-usage of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

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Section: The Emergence Of Drug Resistance Tuberculosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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“…Historically, bacterial pathogens have been a main reason of diseases and death. The development of antimicrobial drugs provided an effective management for bacterial infections [2][3][4][5]. Nowadays, many bacteria have evolved resistance to different antibiotics, and multidrugresistant bacteria have resulted in untreatable infections.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Resistance Patterns in a University Hospital in Al-Kharj City

Ahmed

Khan

2019

JPRI

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Introduction: Antibiotics are medications that are used to kill a bacterium which causes different infections. The misuse of these medications has contributed to the development of bacterial resistance. In order to predict the efficacy of the antimicrobial drugs and to guide antimicrobial therapy, antibiogram should be used. Objective: This study aims to explore the Antibiotic resistance patterns in a university hospital in AL-kharj city. Methods: Data from a university hospital in Al-Kharj city were used to assess the in vitro antimicrobial susceptibility rates for different types of bacteria. We included all bacterial and fungal cultures in the last 2 years. Results: The most common bacterium was E. coli and the most common fungus pathogen was Candida albicans. There was a low resistance rate to gentamicin, imipenem, meropenem and amikacin for the studied bacteria pathogens and high resistance rate for some antibiotics such as erythromycin, tetracycline and ampicillin. Conclusion: The physicians should follow the treatment guidelines and they should know the susceptibility rate of different bacteria to prescribe antibiotics appropriately.

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“…Until today, many TB cases have emerged predominantly in India, Indonesia, China, Myanmar and as recently reported Ethiopia (12), and according to the statistics, these countries contribute to 72% of the global TB burden. The estimates from 2014…”

Section: Introduction To Tuberculosismentioning

confidence: 99%

Characterization of regulatory central stalk epitopes of mycobacterial- and acetogen F-ATP synthases

Bogdanović¹

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Review on emergence of drug-resistant tuberculosis (MDR & XDR-TB) and its molecular diagnosis in Ethiopia

Cited by 46 publications

References 29 publications

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Antibiotic Resistance Patterns in a University Hospital in Al-Kharj City

Characterization of regulatory central stalk epitopes of mycobacterial- and acetogen F-ATP synthases

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