Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Li, Sheng; Wei, Yinling; Liang, Zhenzhen; Guo, Lingli; Hao, Xiaojiang; Zhang, Yu

doi:10.26599/fshw.2022.9250150

Cited by 3 publications

(1 citation statement)

References 231 publications

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“…1, among the brands of health candies in the market, there is 275 (88.4%) consumers recognized the health candies of BY-HEALTH, 53 (17.0%) consumers recognized the healer, and those who recognized other similar brands such as Ligui, Cats & Bears and Munich are in the range of about 20 persons. BY-HEALTH, as a leading company in the production and marketing of various health food products [8]is recognized by close to 90% of consumers.…”

Section: Analysis Of Consumer Perception Of Brands and Functions Of H...mentioning

confidence: 99%

Survey of Cognition and Consumption Behavior of Consumers of Different Ages on Health Candy

Li,

Cheng

2024

IJFSA

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Objective: This study aims to understand the cognition and consumption behavior of consumers of different age groups towards health candies and to understand the functions and sales of health candies on the market. Provide suggestions for the research and future development of new health candy products. Methods: A questionnaire survey was conducted to randomly sample consumers of different age groups. Results: The survey results indicate that there are differences in the perception of health candies among consumers of different age groups. Whether consumers understand health candies is significantly influenced by their age (p<0.01). The older consumers are, the higher their awareness of health candies. However, overall, 32% of consumers are completely unaware of health candies. 44% of consumers have purchased or consumed health candy, and whether consumers have purchased or consumed health candy is significantly influenced by their age (p<0.01); More than 80% of consumers are willing to purchase health candies, among which the product efficacy, taste, and testing reports of health candies are key factors in consumers' purchasing decisions. Conclusion: Health candy should be innovated in terms of efficacy and taste.

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Section: Analysis Of Consumer Perception Of Brands and Functions Of H...mentioning

confidence: 99%

Survey of Cognition and Consumption Behavior of Consumers of Different Ages on Health Candy

Li,

Cheng

2024

IJFSA

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Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease

Flieger,

Forma,

Flieger

et al. 2024

IJMS

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Alzheimer’s disease (AD) is characterized by, among other things, dementia and a decline in cognitive performance. In AD, dementia has neurodegenerative features and starts with mild cognitive impairment (MCI). Research indicates that apoptosis and neuronal loss occur in AD, in which oxidative stress plays an important role. Therefore, reducing oxidative stress with antioxidants is a natural strategy to prevent and slow down the progression of AD. Carotenoids are natural pigments commonly found in fruits and vegetables. They include lipophilic carotenes, such as lycopene, α- and β-carotenes, and more polar xanthophylls, for example, lutein, zeaxanthin, canthaxanthin, and β-cryptoxanthin. Carotenoids can cross the blood–brain barrier (BBB) and scavenge free radicals, especially singlet oxygen, which helps prevent the peroxidation of lipids abundant in the brain. As a result, carotenoids have neuroprotective potential. Numerous in vivo and in vitro studies, as well as randomized controlled trials, have mostly confirmed that carotenoids can help prevent neurodegeneration and alleviate cognitive impairment in AD. While carotenoids have not been officially approved as an AD therapy, they are indicated in the diet recommended for AD, including the consumption of products rich in carotenoids. This review summarizes the latest research findings supporting the potential use of carotenoids in preventing and alleviating AD symptoms. A literature review suggests that a diet rich in carotenoids should be promoted to avoid cognitive decline in AD. One of the goals of the food industry should be to encourage the enrichment of food products with functional substances, such as carotenoids, which may reduce the risk of neurodegenerative diseases.

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UPLC-MS/MS-Based Target Screening of 90 Phosphodiesterase Type 5 Inhibitors in 5 Dietary Supplements

Jin,

Wang,

Ning

et al. 2024

Molecules

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The aim of individuals consuming health supplements is to attain a robust state through nutritional regulation. However, some unscrupulous manufacturers, motivated by profit, fraudulently incorporate drugs or unauthorized components with therapeutic effects into the product for instant product performance enhancement. The long-term use of these products may inadvertently inflict harm on human health and fail to promote nutritive healthcare. The illegal inclusion of these substances is prevalent in kidney-tonifying and sexuality-enhancing products. Developing effective analytical methods to identify these products and screen for illegal added ingredients can effectively prevent such products from reaching and remaining on the market. A target screening method for the detection and quantification of 90 phosphodiesterase type 5 inhibitors (PDE-5is) in 5 kinds of health products was developed and validated. The type of dietary supplements varied from tablets, capsules, and protein powder to wine and beverages. Sample preparation was completed with a one-step liquid phase extraction. The screening process of 90 PDE-5is was done efficiently within 25 min by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) using the dynamic multiple reaction monitoring (dMRM) technique. The LODs of 90 PDE-5is were detected at levels ranging from 25 to 85 ng/g or ng/mL. This novel targeting methodology was effective and can be applied to routine market supervision. Among 286 batches of samples, 8 batches were found to be positive. Three kinds of PDE-5is were first detected in healthy products. The screening method demonstrated herein will be a promising and powerful tool for rapid screening of PDE-5is.

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Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Cited by 3 publications

References 231 publications

Survey of Cognition and Consumption Behavior of Consumers of Different Ages on Health Candy

Survey of Cognition and Consumption Behavior of Consumers of Different Ages on Health Candy

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease

UPLC-MS/MS-Based Target Screening of 90 Phosphodiesterase Type 5 Inhibitors in 5 Dietary Supplements

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