Review on dermatomycosis: pathogenesis and treatment

Abstract

Dermatophytes, a group of keratinophilic fungi thriving on the keratin substrate are the etio-logical agents responsible for causing cutaneous infections. Dermatophytosis is currently treated with the commercially available topical and oral antifungal agents in spite of the existing side effects. Treatment of these cutaneous infections with secondary metabolites produced by marine microorganisms is considered as a novel approach. For many years these organisms have been explored with the view of developing antibacterial, antifungal, antiviral, anti- cancer and antiparasitic drugs. Exploring the unexplored aspect of actinobacteria for developing antidermatophytic drugs is a novel attempt which needs further investigation

Bioclimatologie des infections cutanées mycosiques à Sfax (Centre-Est de la Tunisie)

“…Le nombre d'hospitalisations pour de telles infections a augmenté de 29 % entre 2000 et 2004 (Edelsberg et al, 2009). Le climat chaud présent durant toute l'année et les précipitations abondantes peuvent favoriser la reproduction des agents pathogènes à l'intérieur et en dehors des organismes biologiques (Lakshmipathy et Kannabiran, 2010). Les maladies cutanées sont moins fréquentes sous climat tempéré, en partie en raison d'une saison froide durant laquelle la population d'insectes et les agents pathogènes associés hibernent (Dowell, 2001).…”

Dermatophytes: Diagnosis of dermatophytosis and its treatment

“…These are important to manage infection and public health issues associated with types of Dermatophytosis (Lin et al, 1992). Traditionally, the dermatophytosis is normally referred to as "tinea" or "ring-worm" infections (Lakshmipathy et al, 2010). Damp foot circumstances lead to irritated symptoms due to mixed infection by dermatophytes and bacteria.…”

“…In a special case, the developing countries as India contain infection by the members of the genus Candida (Rao, 1959). Trichophyton concentricum is present in the Far East, India and the pacific's (Ameen, 2010;Lakshmipathy et al, 2010). Microsporum audouinii, Trichophyton violaceum, Trichophyton soudanense are studied in several parts of Africa (Woldeamanuel et al, 2005).…”

“…They cause the surface infections through colonization individually of skin, hairs and nails in human beings known as ringworm, jock itch (Khaksari and Bassiri, 2009;Ryan et al, 2010). The colonies are equipped by generating the Arthospores and conidia of the fungus (Lakshmipathy et al, 2010). Indication of dermatophytosis has a distinction basis in the affected region of the body, but one of their priorities is a universal indicator in humans (Nweze, 2010).…”

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“…Morpholine derivates such as amorolfine and butenafine have been also used 3 . With topical medication, primarily mild skin reactions may occur at the site of application 24 . For patients displaying wide areas of infection or in cases of severe or constant infections, oral therapy should be considered and the same is true for infections caused by T. unguium and T. capitis, where itraconazole, fluconazole, griseofulvin, and ketoconazole are the subjected antifungals to be used 3,23 .…”