Review on Bone Disease (Osteoporosis) in Diabetes Mellitus

El-Tawdy, Ahmed Hassan Fawzi; Ibrahim, Eissa Abdel Hamed; Sakhawy, Eman Mahmoud Aly Al; Morsy, Tosson A

doi:10.21608/jesp.2017.77962

Cited by 4 publications

(7 citation statements)

References 54 publications

(37 reference statements)

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“…About 30% of all postmenopausal women are affected by osteoporosis. 3 Although the relationship between DM and osteoporosis has been known for about half a century, this relationship has begun to be further investigated in the last 10-15 years. Osteoporosis due to diabetes is caused by chronic hyperglycemia, advanced glycated end products, and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoporosis due to diabetes is caused by chronic hyperglycemia, advanced glycated end products, and oxidative stress. 3 - 8 …”

Section: Discussionmentioning

confidence: 99%

“…Although the relationship between DM and osteoporosis has been known for many years, clinical screenings have begun to be performed recently. 3 Patients with T2DM were determined to have an increased risk of fracture, even though they have higher BMD values than individuals without diabetes. The reason for this is explained by the fact that the risk of falls in individuals with diabetes is higher.…”

Section: Introductionmentioning

confidence: 99%

“…The reason for this is explained by the fact that the risk of falls in individuals with diabetes is higher. 3 , 4 Bone disorders have increased in both Type1 and T2DM patients, albeit through different mechanisms. Decreased bone strength due to low bone turnover has been identified in both types of diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effect of Dapagliflozin and Pioglitazone on the risk of osteoporosis in postmenopausal women with Type-2 diabetes

SON

2023

Pak J Med Sci

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Objective: Type 2 Diabetes mellitus (T2DM) and osteoporosis, which increase with age, are two common diseases with different complications. The risk of fractures due to osteoporosis is 2 to 6 times higher in patients with diabetes mellitus (DM). Medications used in the treatment of DM in addition to the disease itself are associated with the risk of osteoporosis and osteoporotic fractures. This study was planned to examine the effects of pioglitazone and dapagliflozin, used in the treatment of T2DM, on the development of osteoporosis in postmenopausal women. Methods: This single-centre comparative study was conducted at Endocrine and Metabolic Diseases Polyclinic of a Hospital between April 15, 2019 and April 15, 2020, with a total of 80 postmenopausal female patients with a diagnosis of T2DM and 20 in the control group, aged between 50 and 70. The participants were evaluated under four groups: “Control” without diabetes mellitus (n=20), “Pioglitazone” using (n=30), “Dapagliflozin” using (n=30), and “Other Oral Antidiabetic” using (n=20). Results: The mean age of the participants was 61.32±6.27 years. There was no statistically significant difference between the groups in the hip and waist T-score values of participants with T2DM in the study (p>0.05). There was no significant difference in waist and hip t-score values between the intervention groups. Pioglitazone and dapagliflozin used in postmenopausal T2DM patients were determined not to make a significant difference in waist and hip bone mineral density values. Conclusion: Our study revealed that pioglitazone and dapagliflozin can be used in postmenopausal T2DM individuals without known osteoporosis and other osteoporosis risk factors. doi: https://doi.org/10.12669/pjms.39.5.7580 How to cite this: Son O. Comparison of the effect of Dapagliflozin and Pioglitazone on the risk of osteoporosis in postmenopausal women with Type-2 diabetes. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7580 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

“…Osteoporosis due to diabetes is caused by chronic hyperglycemia, advanced glycated end products, and oxidative stress. 3 - 8 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of the effect of Dapagliflozin and Pioglitazone on the risk of osteoporosis in postmenopausal women with Type-2 diabetes

SON

2023

Pak J Med Sci

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“…Zoonotic parasites are one of the causes of gastrointestinal troubles, growth retardation, malnutrition, and increasing metabolic disorders in immunocompromised persons as diabetic patients (Zibaei et al, 2023). Meanwhile, both diabetes type 1 & 2 were encountered in Egypt (El-Tawdy et al, 2017). The diabetes alters several immune responses causing suppression in innate and acquired immunity ending in an immune-suppression state (Waly et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Opportunistic Protozoa Coinfected With Helicobacter Pylori Among Egyptian Diabetic Patients

MORSY,

GHALLAB,

ISMAIL

et al. 2024

Journal of the Egyptian Society of Parasitology

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Diabetes mellitus (DM) is a hyperglycemic state wherein the patient has a high level of blood glucose. People with diabetes are vulnerable to infection with opportunistic intestinal parasites as it is considered a state of immune suppression.The study evaluated the opportunistic protozoa co-infected with Helicobacter pylori among 156 DM patients and estimated the risk factors. Early morning stool samples were obtained from each participant and examined for H. pylori and intestinal protozoa. The overall rate of protozoa was 79.5% (124/156), which were Blastocystis hominis, Cryptosporidium parvum and Isospora belli were detected in 13.5%, 29.5%, &16.7% respectively. Giardia intestinalis and Entamoeba histolytica/dispar were in 9% & 8.3% respectively. The overall rate of H. pylori was 19.9%, and its co-infection with I. belli, C. parvum, E. histolytica/dispar, G. intestinalis was 6.4%, 32.2%, 12.9% & 9.6% respectively. A significant relation was between H. pylori and diarrhea (P <0.001), C. parvum and abdominal pain (P=0.001), diarrhea (P <0.001), and animal contact (P <0.001), but I. belli showed a significant association with diarrhea (P = 0.002), flatulence (P = 0.027), and animal contact (P = 0.002).

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Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

Wang

Yang

et al. 2021

Phytotherapy Research

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Decrepitude and apoptosis of bone mesenchymal stem cells (BMSCs) induced by reactive oxygen species (ROS) lead to inhibited osteogenic differentiation, causing decreased bone density and osteoporosis. Quercetin, a bioactive component of Solanum muricatum extracts, promotes the osteogenic differentiation of BMSCs and ameliorates the symptoms of osteoporosis in vivo. However, the detailed mechanism underlying this process remains unclear. The study aims to reveal the regulatory mechanism of quercetin in BMSCs. Mouse BMSCs (mBMSCs) were isolated from the bone marrow and characterized by flow cytometry. QRT-PCR and western blot assays were performed to evaluate the expression levels of related genes and proteins. Alkaline phosphatase (ALP) staining and Oil Red O staining of lipids were used to estimate the osteogenesis and adipogenesis levels of mBMSCs, respectively. Quercetin treatment (2 and 5 μM) induced significant upregulation of antioxidant enzymes, SOD1 and SOD2, in mBMSCs. Quercetin promoted osteogenic differentiation and inhibited adipogenic differentiation of mBMSCs. Quercetin treatment enhanced the phosphorylation of AMPK protein and upregulated the expression of SIRT1, thus activating the AMPK/SIRT1 signaling pathway in mBMSCs. Quercetin promoted osteogenic differentiation and antioxidant responses of mBMSCs by activating the AMPK/SIRT1 signaling pathway.

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Review on Bone Disease (Osteoporosis) in Diabetes Mellitus

Cited by 4 publications

References 54 publications

Comparison of the effect of Dapagliflozin and Pioglitazone on the risk of osteoporosis in postmenopausal women with Type-2 diabetes

Comparison of the effect of Dapagliflozin and Pioglitazone on the risk of osteoporosis in postmenopausal women with Type-2 diabetes

Opportunistic Protozoa Coinfected With Helicobacter Pylori Among Egyptian Diabetic Patients

Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

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