Review on Biodentine-A Bioactive Dentin Substitute

Priyalakshmi., S; Ranjan, Manish

doi:10.9790/0853-13131317

Cited by 26 publications

(4 citation statements)

References 27 publications

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“…The hydroxyl ions produced from Biodentine develop their mechanism of action. Hydroxyl ions are highly active molecules that reversibly or irreversibly inactivate the cellular cytoplasmic membrane enzymes, inhibiting microorganisms' growth (22) .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Evaluation of Different Pulp Capping Materials.

Fetouh,

Noaman,

abed elghany

2024

Al-Azhar Journal of Dental Science

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Objective: Three different pulp capping compounds, Dycal, Rootdent MTA, and Biodentine, were assessed for their antibacterial effectiveness against Streptococcus mutans and Enterococcus facials microorganisms and were investigated by agar diffusion test. Materials and methods: A total of (10) sterilized Petri plates of agar were arbitrarily assigned into 2 groups conferring on the type of tested microorganisms applied (n=5); A1 and A2 for Streptococcus mutans and Enterococcus facials, respectively. In each group, the experimented materials were classified into three major groups: I, II, and III corresponding to Dycal, Rootdent MTA, and Biodentine. Every major group was divided into three distinct subgroups based on the observation periods: (TB1), (TB2), and (TB3) observed after 1, 2, and 7 days, respectively, in order to examine the presence of growth inhibition zones (GIZs) that developed around pulp capping materials. Using a digital micrometer, the size of bacterial growth inhibitory zones was measured to the closest hundredth of a millimeter. Results: All tested materials exhibited antibacterial activity against both tested microorganisms. In Streptococcus mutans, in (TB1), the greatest diameter of bacterial GIZs was performed around Biodentine, followed by Rootdent MTA and Dycal, respectively. In Enterococcus facials, the greatest diameter of bacterial GIZs was formed around Rootdent MTA at all evaluation periods, followed by Biodentine and Dycal, respectively. Conclusions: All the tested bioactive materials effectively inhibit the growth of both microorganisms. Rootdent MTA was more effective against Enterococcus facials, Biodentine was more effective against Streptococcus mutans, while Dycal was the least effective material against both microorganisms.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Evaluation of Different Pulp Capping Materials.

Fetouh,

Noaman,

abed elghany

2024

Al-Azhar Journal of Dental Science

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“…Biodentine has been used for various vital pulp therapies such as direct and indirect pulp capping in human randomized control trials, clinical trials, and animal and in vitro studies [1,[5][6][7][8][9][10]. Biodentine allows the dentist to achieve biomimetic [11] mineralization in a carious lesion [12]. Biodentine, known as "dentin in a capsule," has excellent handling properties [13] and better compressive strength [3].…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Fluoride Release and Compressive Strength of Biodentine Modified Using Sodium Fluorosilicate and Hydrofluoric Acid: An In-Vitro Study

Sekhar,

Shobana,

Kavitha

2023

Cureus

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Introduction Calcium trisilicate derivatives have widely been used as dentin and enamel substitutes recently. These cements have excellent biological properties, but they do not show fluoride release. The release of fluoride from dental materials is a very important property of a material in restorative applications as fluoride confers antibacterial and anti-cariogenic properties. This study thus attempts to incorporate fluoride in the form of sodium fluorosilicate and hydrofluoric acid into Biodentine to assess its fluoride-releasing properties. Methods Biodentine was modified by adding 7% sodium fluorosilicate in the powder and 10% hydrofluoric acid to the liquid. Fluoride release was measured using a sodium 2-(parasulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonate (SPADNS) spectrophotometer after 1, 3, 7, 14, 21, and 28 days. The compressive strength of the modified material was measured using a universal testing machine. Results Fluoride release was found to be higher in the group that had both powder and liquid modified than in groups in which either of the components were modified. The difference was found to be statistically significant (p<0.001). Conclusion Incorporation of fluoride in Biodentine is feasible with acceptable release of fluoride without adversely affecting the compressive strength of the Biodentine.

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“…To overcome the weaknesses of the MTA, Biodentine was marketed as a dental substitute. 12 , 13 This material can be used similar to MTA, with similar indications, to induce the formation of a mineralized barrier in cases of pulp capping. 14 In addition, it has the advantage of reducing the setting time, ease of handling, and better mechanical and biological properties.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity assessment of Bio-C Repair Íon+: A new calcium silicate-based cement

Klein-Júnior

Zimmer

Dobler

et al. 2021

J Dent Res Dent Clin Dent Prospects

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Background. Direct pulp capping is a method designed to preserve the exposed dental pulp. Due to good biological, physical, and mechanical properties, new versions of calcium silicate-based materials have been developed as pulp capping materials. The present study aimed to evaluate the cytotoxic effects of four calcium silicate-based pulp capping materials, of which the Bio-C Repair Íon+ is still in an experimental phase. Methods. Biodentine, MTA Repair HP, Bio-C Repair, and Bio-C Repair Íon+ cements were dispensed in a metallic matrix to produce 125-mm3 specimens, which were immersed in Dulbecco’s Modified Eagle Medium (DMEM) to obtain extracts. NIH 3T3 cells were cultured and exposed to the extracts for 24 hours and seven days. Cell viability was assessed by the methyl tetrazolium test (MTT). The mean values for the experimental and control groups (without treatment) were compared by analysis of variance (ANOVA) and post hoc Tukey tests, considering a significance level of 5%. Results. All the tested materials demonstrated a reduction in cell viability (P<0.05). According to ISO 10993-5: 2009 (E), Bio-C Repair Íon+ exhibited mild and moderate cytotoxicity in the 24- hour and 7-day analyses, respectively. Bio-C Repair and Biodentine showed mild cytotoxicity, and MTA Repair HP exhibited moderate cytotoxicity at both intervals. Conclusion. The highest cell viability was demonstrated by Biodentine, MTA, and Repair HP, in descending order. Bio-C Repair and Bio-C Repair Íon+ showed moderate cytotoxicity, similar to MTA Repair HP in the 7-day analysis.

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Review on Biodentine-A Bioactive Dentin Substitute

Cited by 26 publications

References 27 publications

Antimicrobial Evaluation of Different Pulp Capping Materials.

Antimicrobial Evaluation of Different Pulp Capping Materials.

Comparative Evaluation of Fluoride Release and Compressive Strength of Biodentine Modified Using Sodium Fluorosilicate and Hydrofluoric Acid: An In-Vitro Study

Cytotoxicity assessment of Bio-C Repair Íon+: A new calcium silicate-based cement

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