Review on Analytical and Biological Applications of Hydrazones and their Metal Complexes

Abstract

Hydrazones are very important group of analytical regents for the determination of various metal ions by using various analytical techniques. Besides this use of hydrazones are also having biological activities also. In this paper we first discussed about the chemical nature of hydrazones and their biological activities. We mainly focused on the papers which were published during 1980-2011 on analytical applications (spectrophotometric and spectrofluorimetric) of hydrazones. We gave the total established conditions for the determination of various metal ions with hydrazones.

Synthesis, Characterization, and Photophysical Studies of Some Novel Ruthenium(II) Polypyridine Complexes Derived from Benzothiazolyl hydrazones

“…In the UV-vis absorption spectra of ligands 3a, 3d, and 3e, the absorption at 330, 323, and 323 nm is attributed to - * transitions involving the benzothiazolylhydrazone [10,29]. The band observed at 370 nm is assigned to the - * transition of azomethine (C=N) group [30].…”

“…The polypyridine complexes of Ru(II) have been studied extensively with the point of interest being their rich and well characterized photophysics [6,7]. In recent years, transition metal complexes have been used extensively in the fore front of fields such as probes of DNA structure, DNAdependent electron transfer, and site-specific DNA cleavage [8][9][10]. The area of metal complexes with hydrazones has been investigated intensively during the last years regarding their pharmacological applications such as tuberculostatic, antitumor, antibacterial, and antifungal agents [10][11][12].…”

“…The area of metal complexes with hydrazones has been investigated intensively during the last years regarding their pharmacological applications such as tuberculostatic, antitumor, antibacterial, and antifungal agents [10][11][12]. The thiazole and benzothiazole hydrazone represent a very interesting class of ligands, due to additional donor sites: nitrogen, sulphur, or oxygen atom which introduce a wide range in their coordinative and pharmaceutical properties [10,[13][14][15].…”

1-Indanone chalcones and their 2,4-Dinitrophenylhydrazone derivatives: Synthesis, physicochemical properties and in vitro antibacterial activity

“…Hydrazones (aryl-, heteroaryl, acyl and sulfonyl) have been reported to exhibit diverse biological properties such as anti-tubercular, anti-malarial, antimicrobial, antitumor, anti-inflammatory, anticonvulsant, analgesic, etc, activities and possess varied analytical applications (Rollas and Küçükgüzel, 2007;Ajani et al, 2010;de Oliveira et al, 2011;Suvarapu et al, 2012). It is pertinent to point out here that the development of drug resistance in human pathogens against commonly used antibacterial drugs, resulting in relapse of disease, has necessitated the search for new antimicrobial agents from both natural and synthetic sources.…”

Structural Evaluation and Antibacterial Sensitivity of Iron (III) Complexes of 4-<i>n</i>-hexyloxybenzoylhydrazine with Some Aliphatic and Aromatic

“…Some of the above chelators effectively mobilize Fe from prelabeled cells and prevent Fe uptake from transferrin by the cell in addition to exhibit low cytotoxicity. Moreover, aroylhydrazinato iron(III) complexes play and important role in exhibiting antimicrobial activities as well as in the determination of metal ions in various environmental matrices [8]. As a continued interest in this area, the present work was aimed to prepare several N-alky/aryl substituted aroylhydrazones and to investigate into their antibacterial activities.…”